Clinical trial · Interventional
Desflurane and Postoperative Sleep Quality in Patients Undergoing Elective Breast Surgery
Effect of Desflurane on Postoperative Sleep Quality in Patients Undergoing Elective Breast Surgery: A Non-inferiority Randomized Controlled Trial
NCT04805775CI-TRIAL-00066813completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study intends to investigate the effects of desflurane on postoperative sleep quality to guide perioperative patient management.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Tumor | Breast Neoplasm | ALIAS | 0.90 |
| Desflurane | — | UNRESOLVED | — |
| Postoperative Sleep | — | UNRESOLVED | — |
| Propofol | — | UNRESOLVED | — |
| PSQI | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Desflurane Inhalation | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Desflurane Inhalation Group
- description
- Anesthesia maintenance: Desflurane inhalation (MAC 1.0-1.2) Sufentanil 0.3-0.5 μg / (kg·h) Cisatracurium 1-3 μg / (kg·min)
- interventionNames
- Drug: Desflurane Inhalation
- type
- ACTIVE_COMPARATOR
- label
- Propofol Group
- description
- Anesthesia maintenance: Propofol TCI: 3-4ug / ml Sufentanil 0.3-0.5 μg / (kg·h) Cisatracurium 1-3 μg / (kg·min)
- interventionNames
- Drug: Desflurane Inhalation
Primary outcomes (1)
- measure
- Pittsburgh sleep quality index
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: 1. Undergoing elective breast surgery 2. Age 18-75 years old 3. ASA-PS grade I or II 4. Those who voluntarily participate in the research and sign the informed consent Exclusion Criteria: 1. Cognitive impairment (MMSE \<27) before the operation 2. The patients received adjuvant chemotherapy before the operation 3. At present, they are taking psychoactive, opioid, anti-anxiety, and hypnotic drugs 4. Known or treated patients with obstructive sleep apnea 5. Patients with other cancers
References
Publications (1)
- DERIVEDWang X, Xiong B, Wu T, Liu X, Li K, Wang S, Deng MG, Peng M. Effect of desflurane maintenance on postoperative sleep quality in patients undergoing elective breast surgery: A non-inferiority randomized controlled trial. Sleep Med. 2024 Sep;121:287-294. doi: 10.1016/j.sleep.2024.07.022. Epub 2024 Jul 17. PMID 39038404