Clinical trial · Interventional
US Guided Erector Spinae Plane Block in Breast Cancer Surgery: Analgesia, Spread and Immunomodulation
Ultrasound Guided Erector Spinae Plane Block in Breast Cancer Surgery: Analgesia, Spread and Immunomodulation
NCT04796363CI-TRIAL-00057693completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Prospective interventional study
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Analgesia | — | UNRESOLVED | — |
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Erector Spinae Plane Block with Bubivacaine | Procedure | — | UNRESOLVED |
| Standard General Anaesthesia | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- ESPB Bubivacaine 0.25%
- description
- 20 patients will receive US-guided deep ESPB block before induction of general anaesthesia using 20 ml bupivacaine 0.25 % and 5 ml of radiocontrast dye (Omnipaque) at the level of T4.
- interventionNames
- Procedure: Erector Spinae Plane Block with Bubivacaine
- type
- ACTIVE_COMPARATOR
- label
- ESPB Bubivacaine 0.125%
- description
- 20 patients will receive US-guided deep ESPB block before induction of general anaesthesia using 40 ml bupivacaine 0.125 % and 5 ml of radiocontrast dye (Omnipaque) at the level of T4.
- interventionNames
- Procedure: Erector Spinae Plane Block with Bubivacaine
- type
- PLACEBO_COMPARATOR
- label
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria:ASA physical status 1 or 2 scheduled for mastectomy under the effect of General Anaesthesia \- Exclusion Criteria: 1. Patient refusal. 2. Allergy or contraindication to any of the studied medications or anaesthetic agents. 3. Chronic opioid analgesic use. 4. Pregnancy. 5. Morbid obesity (BMI ≥ 40 kg/m2). 6. Scoliosis or any vertebral anomalies or previous spinal surgeries. 7. Infection at the site of injection or any other contraindication for regional anaesthesia. 8. Duration of surgery more than 90 minutes. 9. Renal impairment.
References
Publications (1)
- DERIVEDAbdella AMMR, Arida EEAEM, Megahed NA, El-Amrawy WZ, Mohamed WMA. Analgesia and spread of erector spinae plane block in breast cancer surgeries: a randomized controlled trial. BMC Anesthesiol. 2022 Oct 17;22(1):321. doi: 10.1186/s12871-022-01860-w. PMID 36253729