Clinical trial · Interventional
Study of ADG106 In Combination With PD-1 Antibody In Advanced or Metastatic Solid Tumors and/or Non Hodgkin Lymphoma
A Multicenter, Open-Label, Phase Ib/II Study of ADG106 in Combination With PD-1 Antibody in Advanced Solid Tumors and Relapsed/Refractory Non-Hodgkin Lymphoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): The safety of ADG106 combined with triprilimab has been fully understood.The overall clinical benefit of enrolled subjects was limited and further development of ADG106 was reconsidered.
Summary
Brief summary (as posted)
This is a Multicenter, Open-Label, Phase Ib/II Study of ADG106 in Combination with PD-1 Antibody in Advanced Solid Tumors and Relapsed/Refractory Non-Hodgkin Lymphoma. The primary objective of Phase Ib: To evaluate the maximum tolerated dosage (MTD) of ADG106 in combination with PD-1 antibody in advanced solid tumors and relapsed/refractory non-Hodgkin lymphoma, and to determine the recommended phase II clinical studies dosage (RP2D).
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Non Hodgkin Lymphoma | Non-Hodgkin Lymphoma | ONTOLOGY_EXACT | 0.90 |
| Solid Tumor | Solid Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| ADG106 injection | Biological | — | UNRESOLVED |
| PD-1 antibody injection | Biological | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- ADG106 combined with PD-1 antibody Dose Escalation Level 1
- interventionNames
- Biological: ADG106 injection
- Biological: PD-1 antibody injection
- type
- EXPERIMENTAL
- label
- ADG106 combined with anti PD-1 antibody Dose Escalation Level 2
- interventionNames
- Biological: ADG106 injection
- Biological: PD-1 antibody injection
- type
- EXPERIMENTAL
- label
- ADG106 combined with anti PD-1 antibody Expansion Phase
- interventionNames
- Biological: ADG106 injection
- Biological: PD-1 antibody injection
Primary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with advanced solid tumors or relapses/refractory non-Hodgkin's lymphoma confirmed by histology or cytology * Has at least one measurable lesion (solid tumor according to RECIST v1.1 criteria, non-Hodgkin's lymphoma according to Lugnao criteria) * ECOG score of 0 or 1; * Expected survival time ≥ 3 months (at the discretion of the investigator); * Adequate organ and bone marrow function; * Voluntarily sign the informed consent form; Exclusion Criteria: * Has central nervous system primary malignant tumor, active epileptic seizure, spinal cord compression or carcinomatous meningitis * The previous anti-tumor treatment has not passed the prescribed washout period * HIV antibody is positive, or with other acquired/congenital immunodeficiency disease, or with history of organ transplantation; * Active hepatitis B or hepatitis C virus (HCV) antibody was positive; * Patients who are pregnant or lactating; * Known or suspected hypersensitivity to the study drug or its pharmaceutical excipients (including mono-hydrate citric acid, sodium di-hydrate citric acid, mannitol, polysorbate, arginine, succinic acid); * Any active autoimmune disease, or known history of autoimmune disease, or syndrome requiring systemic steroids or immunosuppressive medications (other than controlled thyroid disease with alternative therapy/non-immunosuppressive therapy); * Participation in another therapeutic or interventional clinical study in the meantime; * Other circumstances where the investigator considers it is not appropriate to participate in the study.
References
Publications (0)
Data not yet available