Clinical trial · Interventional
MEP and Neuromuscular Blocker
Quantitative Analysis Between Neuromuscular Blocking Agent and Motor Evoked Potential and Analysis of Risk Factors for the Coefficient of Variance of Motor Evoked Potential in Patients Undergoing Brain Tumor Removal Surgery: Population Approach
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
It is important to predict the influence of the neuromuscular blocking agents on the motor evoked potential. Investigator will investigate the dose-response relationship between the degree of the neuromuscular blockade and the motor evoked potential in patients undergoing brain tumor surgery using the population approach. Investigator will investigate the influence of the other factors such as the impedence, reactance, muscel amount, and age on the motor evoked potential.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Tumor | Brain Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Arm I (MEP) | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- rocuronium
- description
- Neuromuscular blockade will be performed using rocuronium.
- interventionNames
- Drug: Arm I (MEP)
Primary outcomes (1)
- measure
- Amplitude of the motor evoked potential
- timeFrame
- At intraoperative 0 hr from the start of the anesthetic induction
- description
- Amplitude of the motor evoked potential will be evaluated at intraoperative 0 h from the start of the anesthetic induction.
Secondary outcomes (1)
- measure
- Amplitude of the motor evoked potential
- timeFrame
- At intraoperative 0 h from the opening of the dura
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 19 Years
Show eligibility criteria text
Inclusion Criteria: 1\. Patients aged 19 years old or older, with American Society of Anesthesiologists Physical Status 1-3, and scheduled for elective brain tumor surgery under the monitoring of the motor evoked potential Exclusion Criteria: 1. Central or peripheral neuromuscular disease 2. Sensory or motor nerve disorder 3. Allergy to propofol, remifentanil, and rocuronium 4. Patients with pacemaker
References
Publications (0)
Data not yet available