Clinical trial · Interventional
Body Composition and Nutritional Status in Pediatric Patients With Hematological Malignancies
Evaluation of Body Composition and Nutritional Status in Pediatric Patients With Hematological Malignancies
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Introduction: Annually 400,000 children are diagnosed with cancer in the world. Approximately 90% live in low/middle-income countries, with survival rates of 10-30%. In Mexico, children and adolescents' hospital admissions for cancer are mainly leukemias (46%), being acute lymphoblastic leukemia (ALL) the most common. Half of ALL patients have an altered nutritional status at the time of diagnosis. Nutritional assessment is performed using conventional anthropometric measures, which are not sensitive to changes in fat-free mass and fat mass (FFM and FFM). Our objective is to evaluate the body composition and nutritional status in pediatric patients with HM. This is a pre-test/post-test clinical trial. Children 2-14 y olds diagnosed with leukemia, myeloma and lymphoma in any stage of oncological treatment will participate. The nutritional status will be evaluated using questionnaires and body composition. Measurements will occur at the enrrollment of the study and 6 months after.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Childhood Cancer | Childhood Malignant Neoplasm | ALIAS | 0.90 |
| Childhood Obesity | — | UNRESOLVED | — |
| Child Malnutrition | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| D2O dilution technique | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Patients diagnosed with HM
- description
- As it is a pre-test / post-test design, the child himself will be the control at the end of the study. Additionally, children without ALL of the same age and sex will be taken as reference. The potential of including paired measurements against healthy children for external control is analyzed.
- interventionNames
- Diagnostic Test: D2O dilution technique
Primary outcomes (6)
- measure
- FFM 1
- timeFrame
- at enrrollment
- description
- Fat free mass in kilograms (Kg)
- measure
- FFM 2
- timeFrame
- 6 months
- description
- Fat free mass in kilograms (Kg)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 2 Years
- Maximum age
- 14 Years
Show eligibility criteria text
Inclusion Criteria: * Patients in remission stage (4 - 6 weeks) * Life expectancy\> 6 months and sufficient general conditions according to scales (Lansky ≥ 50 points for children \<16 years) * Histopathological/molecular clinical confirmation of the HM diagnosis * Signature of the consent by the relative or legal guardian of the patient and as well as the consent informed by the patient. Exclusion Criteria: * Pathological conditions that can alter body composition (diabetes, hypothyroidism, among others) * Patients with sepsis that causes hemodynamic compromise and cannot be evaluated * Severely ill patients unable to participate in baseline measurements * Relapsed patients * Patients with developmental problems of a genetic order as well as innate errors of metabolism
References
Publications (65)
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