Clinical trial · Observational
Study on Clinical Features and Outcomes of Breast Sarcoma
Breast Sarcomas: A Retrospective Analysis of Clinical Features and Outcomes
NCT04749446CI-TRIAL-00100048Breast-SarcrecruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is multi-institutional retrospective study in order to identify the most relevant clinical characteristics, treatment strategies, to explore the impact on principal clinical outcomes and finally, to suggest some principles for management and treatment of breast sarcomas. The study will collect data about patients affected by breast sarcoma referred to participating Institutions between January 2000 and June 2020
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Sarcoma | Breast Sarcoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Treatment of Breast Sarcoma according clinical practice (includes drugs, surgery or any other received treatments) | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Breast sarcoma
- description
- This cohort include patients affected by breast sarcoma, referred to participating Institutions between January 2000 and June 2020.
- interventionNames
- Other: Treatment of Breast Sarcoma according clinical practice (includes drugs, surgery or any other received treatments)
Primary outcomes (2)
- measure
- Treatments received for breast sarcoma
- timeFrame
- At diagnosis (baseline) and after 6, 12, 18, 24, 36, 48 and 60 weeks
- description
- To describe treatment that patient diagnosed with breast sarcoma, received
- measure
- Number of patients with primary breast sarcoma
- timeFrame
- Through study inclusion period, an average of 20 years
- description
- Number of patient with a diagnosis of primary breast sarcoma
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 19 Years
Show eligibility criteria text
Inclusion Criteria: * \>18 years at diagnosis * primary or secondary breast sarcoma * availability of medical data needed for the study (histopathological data, surgery, chemotherapy, including preceding chemotherapeutic regimens for secondary breast sarcomas, radiation therapy) Exclusion Criteria: * sarcoma metastases to the breast * chest wall sarcomas not arising in the mammary gland * cutaneous sarcomas
References
Publications (7)
- BACKGROUNDAl-Benna S, Poggemann K, Steinau HU, Steinstraesser L. Diagnosis and management of primary breast sarcoma. Breast Cancer Res Treat. 2010 Aug;122(3):619-26. doi: 10.1007/s10549-010-0915-y. Epub 2010 May 18. PMID 20480227
- BACKGROUNDKirova YM, Gambotti L, De Rycke Y, Vilcoq JR, Asselain B, Fourquet A. Risk of second malignancies after adjuvant radiotherapy for breast cancer: a large-scale, single-institution review. Int J Radiat Oncol Biol Phys. 2007 Jun 1;68(2):359-63. doi: 10.1016/j.ijrobp.2006.12.011. Epub 2007 Mar 26. PMID 17379448
- BACKGROUNDYap J, Chuba PJ, Thomas R, Aref A, Lucas D, Severson RK, Hamre M. Sarcoma as a second malignancy after treatment for breast cancer. Int J Radiat Oncol Biol Phys. 2002 Apr 1;52(5):1231-7. doi: 10.1016/s0360-3016(01)02799-7. PMID 11955733
- BACKGROUNDSheth GR, Cranmer LD, Smith BD, Grasso-Lebeau L, Lang JE. Radiation-induced sarcoma of the breast: a systematic review. Oncologist. 2012;17(3):405-18. doi: 10.1634/theoncologist.2011-0282. Epub 2012 Feb 14. PMID 22334455
- BACKGROUNDHuang J, Mackillop WJ. Increased risk of soft tissue sarcoma after radiotherapy in women with breast carcinoma. Cancer. 2001 Jul 1;92(1):172-80. doi: 10.1002/1097-0142(20010701)92:13.0.co;2-k. PMID 11443624
- BACKGROUNDTrent II JC 2nd, Benjamin RS, Valero V. Primary soft tissue sarcoma of the breast. Curr Treat Options Oncol. 2001 Apr;2(2):169-76. doi: 10.1007/s11864-001-0059-8. PMID 12057135
- BACKGROUNDFields RC, Aft RL, Gillanders WE, Eberlein TJ, Margenthaler JA. Treatment and outcomes of patients with primary breast sarcoma. Am J Surg. 2008 Oct;196(4):559-61. doi: 10.1016/j.amjsurg.2008.06.010. Epub 2008 Aug 23. PMID 18723152