Clinical trial · Observational
Perioperative Troponin I and NT Pro-BNP in Lung Resection
Incidence and Clinical Relevance of Perioperative Elevation of Troponin I and N- Terminal Pro-Brain Natriuretic Peptide in Patients Undergoing Lung Resection
NCT04749212CI-TRIAL-00087199completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
After lung resection, troponin elevation may be regulated by mechanisms other than myocardial ischemia. Perioperative natriuretic peptides measurement may help identify changes in ventricular function during thoracic surgery. Integrating both cardiac biomarkers may improve the predictive value for cardiovascular complications after lung resection.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cardiac Ischemia | — | UNRESOLVED | — |
| Complication,Postoperative | — | UNRESOLVED | — |
| Thoracic Cancer | Malignant Thoracic Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| serum high-sensitivity Troponin I (TnI) and NT-Pro-Brain Natriuretic Peptide (NT-proBNP) | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (3)
- measure
- NT-proBNP perioperative changes
- timeFrame
- Change from baseline NT-proBNP at two-days after surgery
- description
- Perioperative change in NT-Pro-Brain Natriuretic Peptide (NT-proBNP) levels in patients undergoing pulmonary resection. Cutt-of values will be NT-proBNP ≥ 300 pg/ml pg/ml
- measure
- TnI perioperative changes
- timeFrame
- Change from baseline TnI at two-days after surgery
- description
- Perioperative changes in high-sensitivity troponin I (TnI) levels in patients undergoing pulmonary resection. Cutt-of values will be TnI ≥45 ng/L
- measure
- Major cardiovascular complications
- timeFrame
- 30-days after surgery
- description
- Postoperative non-fatal cardiac arrest, acute myocardial infarction, angina, congestive heart failure, new clinically relevant cardiac arrhythmia, cardiovascular death
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 45 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≥45 years old * Patients undergoing elective surgery for lung resection Exclusion Criteria: * Patients undergoing urgent, emergent, or nonthoracic surgery * Patients or family did not consent to participate * Presence of symptoms related with infection or sepsis * Patients with a documented history of severe heart failure and/or ejection fraction lower than 30%
References
Publications (2)
- DERIVEDAlonso M, Popova E, De Miguel M, Garcia-Osuna A, Gonzalez-Tallada A, Ordonez-Llanos J, Jauregui A, Trujillo JC, Martin Grande A, Martinez-Tellez E, Parera A, Planas G, Trujillo L, Butron D, Sola-Roca J, De Nadal M. N-terminal proBNP adds prognostic value to high-sensitivity cardiac troponin I in elective thoracic surgery: an observational cohort study. BMJ Open. 2026 Apr 17;16(4):e108073. doi: 10.1136/bmjopen-2025-108073. PMID 41997702
- DERIVEDAlonso M, Popova E, Martin-Grande A, Perez-Velez J, Trujillo JC, Gajate L, de Miguel M, Gonzalez-Tallada A, Martinez-Tellez E, Cladellas-Gutierrez E, Planas G, de Pablo A, Parise D, Candela-Toha A, de Nadal M. Study protocol for an observational cohort evaluating incidence and clinical relevance of perioperative elevation of high-sensitivity troponin I and N-terminal pro-brain natriuretic peptide in patients undergoing lung resection. BMJ Open. 2022 Dec 8;12(12):e063778. doi: 10.1136/bmjopen-2022-063778. PMID 36600389