Clinical trial · Observational
Outcome of Dental Implant Therapy in Patients Treated With Antiresorptive Medication
NCT04741906CI-TRIAL-00080041unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Aim of the study is to examine the feasibility of dental implant insertion in patients receiving high, adjuvant and low dose \> 4 years.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Implants | — | UNRESOLVED | — |
| Missing Teeth | — | UNRESOLVED | — |
| Osteoporosis | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dental implant surgery | Procedure | — | UNRESOLVED |
| Prosthetic treatment | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (9)
- label
- Patient with osteoporosis - antiresorptive treatment > 4 years. Previous tooth extraction
- description
- Patient with osteoporosis - antiresorptive treatment \> 4 years who have had previous tooth extraction without development of MRONJ
- interventionNames
- Procedure: Dental implant surgery
- Procedure: Prosthetic treatment
- label
- Patient with osteoporosis - antiresorptive treatment > 4 years. Previous resection
- description
- Patient with osteoporosis - antiresorptive treatment \> 4 years who have lost teeth due to having previous osteonecrosis of the jaw which has been successfully surgically treated and healed for at least 3 months without recurrence
- interventionNames
- Procedure: Dental implant surgery
- Procedure: Prosthetic treatment
- label
- Patient with osteoporosis - antiresorptive treatment > 4 years. Simultaneously with resection
- description
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patient with cancer or osteoporosis, treated with antiresorptive treatment. * The patients should have sufficient compliance, this includes willingness to have the planned assessments * The patient should have an expected life span at enrollment of at least 2 years. * The local bone quality and quantity should be sufficient for implant insertion without bone augmentation and is classified according to the classification by Cawood \& Howell 1988. Exclusion Criteria: * \> 10 cigarettes daily * HbA1c \> 53 mmol/mol * Poor oral hygiene * Poor general condition: ECOG score 3 or 4. * Poor prognosis: Expected survival \<2 year is an exclusion cause. * Presence of metastases of the liver brain. * Poor local jaw bone quality acc. to Cawood classification stage 3 or 4. * Unwillingness to comply with the planned assessments and recordings
References
Publications (2)
- DERIVEDOttesen C, Andersen SWM, Jensen SS, Kofod T, Gotfredsen K. Medication-related osteonecrosis of the jaw and successful implant treatment in a patient on high-dose antiresorptive medication: A case report. Clin Exp Dent Res. 2022 Oct;8(5):1059-1067. doi: 10.1002/cre2.620. Epub 2022 Jul 27. PMID 35894761
- DERIVEDAndersen SWM, Ottesen C, Gotfredsen K, Jensen SS, Kofod T, Schiodt M. Outcome of healing after dental implant placement in patients with cancer on high-dose antiresorptive medications: a prospective feasibility study. Oral Maxillofac Surg. 2023 Mar;27(1):89-100. doi: 10.1007/s10006-022-01042-5. Epub 2022 Jan 27. PMID 35084584