Clinical trial · Interventional
Improving Tobacco Treatment Rates for Cancer Patients Who Smoke
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The research objective is to identify a simple, pragmatic, innovative way of enhancing Tobacco Use Treatment (TUT) rates within oncology. To investigate this possibility, the investigators propose methods that will allow them to: 1) evaluate the impact of standing orders to initiate a varenicline management protocol within outpatient cancer treatment workflow, 2) assess the potential for an EHR-based intervention to affect patient TUT behaviors, and 3) identify important facilitators and barriers that impact effectiveness of the intervention. The investigators will assess whether including a standing order for prescription and management of varenicline (TUT Service+VM) within the workflow for cancer patients identified as current smokers will significantly increase TUT engagement rates compared to current standard of care (TUT Service alone). The investigators hypothesize that observed treatment engagement rates will be higher among clinicians exposed to TUT Service+VM than observed in clinicians exposed to TUT Service alone.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Nicotine Dependence | — | UNRESOLVED | — |
| Smoking | — | UNRESOLVED | — |
| Tobacco Use | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Tobacco Use Treatment Service and Varenicline Management | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- Usual Care
- description
- TUT Service Only
- type
- EXPERIMENTAL
- label
- Tobacco Use Treatment Service + Varenicline Management
- description
- TUTS + Varenicline Management
- interventionNames
- Other: Tobacco Use Treatment Service and Varenicline Management
Primary outcomes (1)
- measure
- Intervention Ordering Rate
- timeFrame
- Up to 30 days after Initial Visit
- description
- Defined as the number of patients for whom any inpatient tobacco use treatment order is signed by a participating clinician, divided by the total number of patients in each arm for whom an order was pended and the alert fired
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: 1. Currently in active practice within Medical and Radiation Oncology divisions of ACC, 2. Prescribing authority in Pennsylvania (i.e. physician, nurse practitioner, physician assistant), 3. Nonsmoker, 4. Has cared for at least one patient with tobacco use disorder in the 30 days prior to recruitment, 5. English speaking, and 6. Willing to provide informed consent to participate. Exclusion Criteria: 1. Unwillingness to prescribe varenicline, or 2. Unwillingness to assign varenicline management to TUT Service providers.
References
Publications (1)
- DERIVEDSchnoll R, Blumenthal D, Wileyto EP, Bauer AM, Evers-Casey S, Stevens N, Fisher T, Ware S, Jenssen BP, Wollack C, Schwartz S, Leone FT. Pilot Trial of a Behavioral Economics-Informed Clinical Decision Support Alert to Improve Inpatient Tobacco Use Treatment Rates. Nicotine Tob Res. 2025 Nov 23;27(12):2265-2272. doi: 10.1093/ntr/ntaf129. PMID 40570180