18F-PSMA-1007 PET/CT Imaging in Patients with Biochemically Recurrent or High-risk Prostate Cancer

Inclusion Criteria:

1. Adult patients (≥ 18 years old) with a history of radical prostatectomy for treatment of prostate cancer, and a serum prostate specific antigen (PSA) \> 0.2 µg/L
2. Adult patients (≥ 18 years old) with a history of radiotherapy, cryotherapy, or brachytherapy for treatment of prostate cancer, and a serum PSA progressively rising to ≥ 2 µg/L (minimum two samples) OR a serum PSA doubling-time of \< 9 months
3. Adult patients (≥ 18 years old) with a history of biopsy-proven prostate cancer and high-risk features for metastatic disease prior to treatment with radical prostatectomy, radiotherapy, cryotherapy, or brachytherapy. High-risk features include a Gleason score \> 7, serum PSA \> 20 µg/L, OR minimum clinical T-stage T2c.

Exclusion Criteria:

1. Unable to obtain consent
2. Weight \>225 kg (weight limitation of PET/CT scanner)
3. Unable to lie flat for 30 minutes to complete the PET-CT imaging session
4. Lack of intravenous access
5. Both CT scan of the chest, abdomen, and pelvis and 99mTc-MDP bone scan within 3 months
6. History of allergic reaction to 18F-PSMA-1007 or 99mTc-MDP