Clinical trial · Observational
The Swiss Childhood Cancer Survivor Study - Follow-up (SCCSS-FollowUp)
NCT04732273CI-TRIAL-00095651SCCSS-FUrecruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The SCCSS-FollowUp is a national, multicenter cohort study designed to investigate late effects in childhood cancer survivors in a prospective and longitudinal way. The study is embedded in regular follow-up care and inclusion in the study takes place in a step-wise approach. The investigators collect data from clinical examinations, laboratory and functional tests, and questionnaires to learn more about late effects of childhood cancer treatments.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Childhood Cancer | Childhood Malignant Neoplasm | ALIAS | 0.90 |
| Late Effect | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Personal history, questionnaire | Other | — | UNRESOLVED |
| Physical examination, diagnostic tests, laboratory tests | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (3)
- measure
- Symptoms of organ-specific late effects (example of pulmonary late effects)
- timeFrame
- At baseline
- description
- Number of people with cough or shortness of breath when at risk for pulmonary late effects
- measure
- Signs of organ-specific late effects (example of pulmonary late effects)
- timeFrame
- At baseline
- description
- Number of people with signs of disturbed breathing or abnormal breathing sounds when at risk for pulmonary late effects
- measure
- Tests to assess organ-specific late effects (example of pulmonary late effects)
- timeFrame
- At baseline
- description
- Number of people with abnormal pulmonary function testing (e.g. spirometry, body plethysmography) when at risk for pulmonary late effects
Secondary outcomes (7)
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
This prospective cohort study is based on the Childhood Cancer Registry (ChCR), a national, population-based cancer registry that includes all children and adolescents in Switzerland who were diagnosed with cancer at age 0-20 years. It includes patients diagnosed with leukemia, lymphoma, central nervous system tumors, and malignant solid tumors or Langerhans cell histiocytosis. Inclusion Criteria: * Registered in the Childhood Cancer Registry (ChCR) or treated and followed-up in a Swiss pediatric oncology (SPOG) clinic, but not registered in the ChCR because of residency in neighboring countries * Diagnosed at age 0 - 20 years * Childhood cancer treatment completed * All age categories at time of inclusion in the study (children, adolescents, adults) * Written informed consent Exclusion criteria: * Childhood cancer survivors in a palliative or relapsed situation where no follow-up examinations are foreseen.
References
Publications (1)
- DERIVEDZarkovic M, Schindera C, Sommer G, Schneider C, Usemann J, Otth M, Luer S, Ansari M, Latzin P, Kuehni CE. Assessing Pulmonary Function in Children and Adolescents After Cancer Treatment: Protocol for a Multicenter Cohort Study (Swiss Childhood Cancer Survivor Study FollowUp-Pulmo). JMIR Res Protoc. 2025 Apr 8;14:e69743. doi: 10.2196/69743. PMID 40198919