Clinical trial · Observational
Evaluation of OE-MRI in Patients With H&N Cancer
Evaluation of Oxygen Enhanced Magnetic Resonance Imaging for Identification of Hypoxia Induced Resistant Tumours in Patients With Head and Neck Cancer
NCT04724096CI-TRIAL-00066198completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Assessment of the use of oxygen enhanced MRI scanning in a cohort of patients with head and neck squamous cell carcinomas to identify areas of hypoxia with tumours and relate this to treatment outcomes.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Squamous Cell Carcinoma | Head and Neck Squamous Cell Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Oxygen Enhanced MRI scan | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Non-patient volunteers
- description
- 5 non-patient volunteers for testing of protocol to allow for the ascertaining of good quality data prior to the scanning of patients.
- interventionNames
- Diagnostic Test: Oxygen Enhanced MRI scan
- label
- Patients
- description
- 50 patients to be scanned with the oxygen enhanced MRI scan protocol prior to definitive curative intent therapy.
- interventionNames
- Diagnostic Test: Oxygen Enhanced MRI scan
Primary outcomes (2)
- measure
- Number of patients with areas detected within tumours of the head and neck area that have measurable hypoxia using OE-MRI technique.
- timeFrame
- 2 years
- description
- Feasibility of OE-MRI scans to detect hypoxic areas within tumours in patients with head and neck squamous cell carcinomas
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Inclusion Criteria: Non-patient Volunteer Inclusion Criteria: * Age 18 years and above * Signed written informed consent Patient Inclusion Criteria: * Histologically proven or strong clinical suspicion of squamous cell carcinoma of the head and neck * Suitable for undergoing radical radiotherapy or chemoradiotherapy according to local protocols within the head and neck Cancer MDT * Age 18 years and above * Adequate physical fitness (WHO performance status 0 to 2) * Signed written informed consent Exclusion Criteria: Non-patient Volunteer Exclusion Criteria: * Contraindications to MRI scans as identified following completion of the Nottingham University Hospitals NHS Trust (NUH) standard MR safety screening protocol * Severe Chronic Obstructive Pulmonary Disease (COPD) who are at risk of type 2 respiratory failure or require supplemental oxygen * Volunteers who are pregnant as identified through the NUH standard MR safety screening protocol Patient Exclusion Criteria: * Poor physical fitness (WHO performance status greater than 2) * Contraindications to MRI scans as identified following completion of the NUH standard MR safety screening protocol * Severe Chronic Obstructive Pulmonary Disease (COPD) who are at risk of type 2 respiratory failure or require supplemental oxygen * Patients who are pregnant or breast-feeding (due to IV contrast use in the routine clinical scan) as identified through the NUH standard MR safety screening protocol
References
Publications (1)
- DERIVEDMcCabe A, Martin S, Rowe S, Shah J, Morgan PS, Borys D, Panek R. Oxygen-enhanced MRI assessment of tumour hypoxia in head and neck cancer is feasible and well tolerated in the clinical setting. Eur Radiol Exp. 2024 Mar 6;8(1):27. doi: 10.1186/s41747-024-00429-1. PMID 38443722