Clinical trial · Interventional
Low Contrast Agent and Radiation Dose Protocol for Liver CT in Patients With HCC
Low Contrast Agent and Radiation Dose Protocol Liver CT With Deep-learning-based Contrast Boosting Model in Patients at High Risk for HCC: Prospective, Randomized, Single Blinded - Preliminary Study
NCT04722120CI-TRIAL-00056505completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to investigate the image quality and clinical feasibility of double low-dose liver computed tomography using a deep-learning-based iodine contrast boosting algorithm in participants at high risk for hepatocellular carcinoma.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (5)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Conventional CT (contrast agent) | Drug | — | UNRESOLVED |
| Conventional CT (radiation) | Radiation | — | UNRESOLVED |
| Deep-learning based contrast boosting algorithms | Other | — | UNRESOLVED |
| Low contrast dose CT | Drug | — | UNRESOLVED |
| Low radiation dose CT | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Conventional liver CT
- description
- Underwent conventional liver CT on HCC high-risk patient
- interventionNames
- Radiation: Conventional CT (radiation)
- Drug: Conventional CT (contrast agent)
- type
- EXPERIMENTAL
- label
- Double low dose CT
- description
- Underwent double low dose liver CT with 30% lower radiation dose and 20% contrast media on HCC high-risk patient
- interventionNames
- Radiation: Low radiation dose CT
- Drug: Low contrast dose CT
- Other: Deep-learning based contrast boosting algorithms
Primary outcomes (2)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Liver cirrhosis * Tumor marker (aFP, PIVKA) elevation * Nodular lesion on USG * Received RFA for HCC Exclusion Criteria: * hypersensitivity at iodine * GFR under 30 * BMI over 30 * Nursing or pregnant women * enrolled the other study
References
Publications (0)
Data not yet available
No reference posted for this study.