Clinical trial · Observational
Interval Between Neoadjuvant Therapy and Surgery in the Treatment of Locally Advanced Rectal Cancer (CRONOS)
Interval Between Neoadjuvant Therapy and Surgery in the Treatment of Locally Advanced Rectal Cancer
NCT04717947CI-TRIAL-00049876CRONOSunknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators evaluate the response of rectal cancer to neoadjuvant therapy and classify the response according to specific periods of time after the end of neoadjuvant treatment.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Neoadjuvant Therapy | — | UNRESOLVED | — |
| Rectal Cancer | Malignant Rectal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Interval between NAT and surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Short interval group
- description
- ≤ 8weeks between the end of neoadjuvant therapy and surgery
- interventionNames
- Procedure: Interval between NAT and surgery
- label
- Intermediate interval group
- description
- \> 8 and ≤ 12 weeks between the end of neoadjuvant therapy and surgery
- interventionNames
- Procedure: Interval between NAT and surgery
- label
- Long interval group
- description
- \> 12 weeks between the end of neoadjuvant therapy and surgery
Primary outcomes (4)
- measure
- Pathological response
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Adult patients suitable for elective surgical resection of biopsy-confirmed rectal adenocarcinoma (0-15 cm from the anal verge) determined by rectal cancer protocol magnetic resonance imaging. * Patients treated with long-course neoadjuvant chemoradiotherapy (nCRT). * Patients treated with short-course radiotherapy with delayed surgery. * Clinical stage IIA, IIB, IIIA, IIIB, IIIC (cT3/cT4, or cN1/cN2 with any cT, M0) determined by rectal cancer protocol magnetic resonance imaging Exclusion Criteria: * Intolerance or contraindication to planned NAT. * Patients who have not finished NAT for any reason. * Patients with unknown cT or cM. * Tumors previously treated with local excision or with distant metastatic disease.
References
Publications (0)
Data not yet available
No reference posted for this study.