Clinical trial · Observational
Impact of Ionizing Treatment on the Nuclear Structure of Human Spermatozoa.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Differentiated thyroid cancer is the third cause of cancer in young men of childbearing age. Its treatment by irradiation with Radioactive Iodine 131 therapy (RAT) could alter spermatogenesis and result in azoospermia and permanent infertility. A preventive gametes cryopreservation was recommended before RAT, but without mentioning a period of teratogenic risk transmissible to the offspring. To date, RAT impact on human sperm nucleus is poorly known or even unknown, notably on telomere length. Our objective is to define RAT effects on human sperm nucleus by in vitro irradiation exposure of human spermatozoa to mimicking that of the gonads in the context of irradiation with iodine131 used for thyroid cancer. We will analyze standard sperm parameters, major DNA alterations and telomere length using molecular and cellular assays. Nucleus morphology and chromatin organization will also be analyzed using 3D bio-imaging. This study will permit to optimize the indications for the preservation of fertility.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Irradiated Semen | — | UNRESOLVED | — |
| Sperm Preservation | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Acute and low irradiation | Other | — | UNRESOLVED |
| Cryopreserved semen | Other | — | UNRESOLVED |
| Long and low irradiation | Other | — | UNRESOLVED |
| Long and medium irradiation | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (5)
- label
- control arm "fresh"
- description
- Fresh semen treated without irradiation before cryopreservation
- interventionNames
- Other: Cryopreserved semen
- label
- control arm "cryopreserved"
- description
- cryopreserved semen without irradiation (n=60)
- interventionNames
- Other: Cryopreserved semen
- label
- acute irradiation at low dose
- description
- Pelvis scanning : acute irradiation (1 or 2 second) using low dose (n=30),
- interventionNames
- Other: Acute and low irradiation
- label
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
- Maximum age
- 45 Years
Show eligibility criteria text
Inclusion Criteria: * Man less than 45 years * Man undergoing routine semen analysis at the Center for Reproductive Medicine, accepting the research protocol and signing the associated consent will be included in the protocol without distinction of physical criteria. Exclusion Criteria: \-
References
Publications (0)
Data not yet available