Clinical trial · Interventional
Endobronchial Cryotherapy in Management of MEBO in Patients With Inoperable NSCLC
The Value of Endobronchial Cryotherapy in the Management of Malignant Endobronchial Obstruction in Patients With Inoperable NSCLC: A Prospective Analysis of Clinical and Survival Outcomes
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Background: In end-stage patients when all management options have been used, will often develop compromise of their airways as the cancer continues to progress. Endobronchial therapy options may help to relieve some of their symptoms, allowing improvement in their shortness of breath as they go home in combination with other palliative therapies. Objective: to compare the safety ; efficacy; and clinical outcome of endobronchial cryotherapy combined with chemotherapy and/ or radiotherapy versus chemo-radiotherapy alone on patients with Non small cell lung cancer. Patients and method(s): A prospective randomized clinical trial was carried out on 60 patients with different ages of both sexes, diagnosed as bronchogenic carcinoma non-small cell lung cancer type (NSCLC) . The patients attended the hospital in the chest department, Qena Faculty of Medicine, South Valley University. Assessment of the patients was done and randomly assigned into two groups. Group1 ,Include 30 patients subjected to chemotherapy , radiotherapy and endobronchial cryotherapy.Group 2 , Include include 30 patients subjected to chemotherapy and radiotherapy alone.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bronchogenic Cancer | — | UNRESOLVED | — |
| Non-Small Cell Carcinoma of Lung, TNM Stage 4 | Lung Non-Small Cell Carcinoma | ALIAS | 0.85 |
| Non Small Cell Lung Cancer | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| cryotherapy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Group 1
- description
- it included 30 patients, they were subjected to chemoradiotherapy plus endobronchial cryotherapy.
- interventionNames
- Procedure: cryotherapy
- type
- NO_INTERVENTION
- label
- Group 2
- description
- it included include 30 patients, they were subjected to chemoradiotherapy.
Primary outcomes (4)
- measure
- Evaluation of the clinical changes of the cases after procedure.
- timeFrame
- the symptoms were evaluated before therapy as a baseline; and evaluated 4 weeks after procedure.
- description
- Evaluation of the rate of symptoms relief after therapy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 47 Years
- Maximum age
- 71 Years
Show eligibility criteria text
Inclusion Criteria: * All cases with pathologically proved and inoperable NSCLC cases based on tumor position; in the main and subsegmental bronchi. Exclusion Criteria: * Cases with severe respiratory distress, uncorrectable impaired bleeding profile and prechemotherapy.
References
Publications (0)
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