Immune Profile and Prognosis of Malignant Liver Tumors With Radiofrequency Ablation (RFA) Therapy

Inclusion Criteria:

* Disease characteristics: Patients with primary or metastatic liver cancer judged by histology
* Age: 20 years old or older
* Life expectation: at least 3 months
* Hematology:

  1. Platelet count: at least 50,000/mm\^3
  2. Prothrombin time (PT) or partial thromboplastin time (PTT): no more than 1.5 times the control group
  3. Creatinine: no more than 2.5 mg/dl
* No pregnancy, no rhythm adjuster or other implantable device
* There are no uncontrollable responses to this study
* Other malignant tumors, except for therapeutic non-melanoma skin cancer or cervical cancer 5 years before entering the study inside.
* The number of liver tumors is less than three, the size is less than three centimeters, or the size of a single tumor is less than five centimeters, and those who want to undergo radiofrequency ablation are treated.
* The clotting time is normal and the number of platelets needs to be greater than 50,000, total bilirubin is less than 3 mg/dl, controllable ascites, no extrahepatic metastasis and portal vein invasion, and those who want to undergo radiofrequency ablation.
* The patient refuses or is unable to perform surgery (eg, If the age is too old, for those who want to undergo radiofrequency ablation).
* Patients and their families must fully understand and agree to perform radiofrequency ablation procedures.

Exclusion Criteria:

* There are people with central nervous system metastases.
* Measure lesions only by previous radiotherapy or topical treatment.
* Biliary obstruction did not undergo adequate drainage procedures prior to enrollment.
* White blood cells (WBC) are less than 3,500 / mm3 and absolute neutrophil count (ANC) is less than 1,500 / mm3, platelets less than 100,000 / mm3
* Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) is greater than 5.0 times the upper limit of the normal range (ULN).
* Serum total bilirubin levels are equal to or greater than 2.0 mg / dl.
* Serum creatinine greater than 1.5 mg / dl.
* There are peripheral neuropathies greater than grade 1.
* Concomitant diseases that may accumulate via chemotherapy. For example, active, noncontrolled infection or other activity, non-control Systemic diseases such as congestive heart failure, angina pectoris, respiratory insufficiency, arrhythmia.
* Those who are treated concurrently with other research drugs or other anti-cancer therapies.
* Pregnant or lactating women, or women with fertility potential, unless reliable and appropriate methods of contraception are used.