Ntraperitoneal Thermal Perfusion Combined With Chemotherapy Versus Chemotherapy

Inclusion Criteria:

* Participate voluntarily and sign informed consent;
* Age ≥18 years old and ≤80 years old, regardless of gender;
* Physical condition ECOG 0 \~ 2;
* The diagnosis of pancreatic adenocarcinoma was confirmed by pathology;
* Peritoneal metastasis was confirmed by ascites cytology, or was pathologically confirmed by surgical exploration and biopsy;
* Expected survival ≥3 months;
* No serious abnormal blood system, heart and lung function and immune deficiency (refer to respective standards);
* Blood routine indicators: white blood cell (WBC) ≥3 × 109/L;Absolute count of neutrophils (ANC) ≥1.5 × 109/L;Platelet (PLT) ≥100 × 109/L;Hemoglobin (Hgb) ≥9 g/dL;
* Blood biochemical indexes: AST (SGOT) and ALT (SGPT) ≤2.5 × upper limit of normal value (ULN);Total bilirubin (TBIL) ≤ULN;Serum creatinine (CRE) ≤1.5 × ULN;
* Coagulation function: Prothrombin time (PT), international standard ratio (INR) ≤1.5 × ULN;
* Comply with the study visit plan and other program requirements.

Exclusion Criteria:

* Accompanied by other systemic malignant tumors;
* Received any form of anti-tumor therapy, including interventional chemoembolization, ablation, radiotherapy, chemotherapy, tumor palliative resection and molecular targeted therapy;
* Used any other study drugs within 5 weeks before enrollment;
* Central nervous system diseases, mental diseases, unstable angina pectoris, congestive heart failure, severe arrhythmia and other serious diseases that cannot be controlled;
* Uncontrolled infection, bleeding, pancreatic leakage, bile leakage, or other postoperative complications during baseline examination;Acute and chronic metabolic acidosis (including ketoacidosis and lactic acidosis) has not been corrected.
* A history of allergy to study drugs or similar structured drugs;
* Pregnant or lactating women;
* Any conditions, including serious medical risk factors, medical conditions, and laboratory abnormalities, that may impair patient safety or the integrity of research data;
* Intestinal obstruction, extensive adhesion in the peritoneal cavity, abdominal inflammation, etc.