Clinical trial · Observational
Evaluation of the Success of Prophylactic Enteral Nutrition in Therapeutic Intensification With Autograft of Autologous Hematopoietic Cells in Hematology
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
When the digestive tract is functional, learned societies recommend the use of a nutritional support by enteral feeding. Indeed, it has many advantages (maintenance of gut trophicity, reduction of the risk of infection by reducing the incidence of bacterial translocations,...). It has been used for about fifteen years in hematology departments and offers promising results in the context of allogeneic transplantation with prospective trials in progress (NEPHA study). However, its tolerance has not been studied during autologous transplantation. This study aims to assess the success of enteral nutrition in this setting.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lymphoma | Lymphoma | ONTOLOGY_EXACT | 0.90 |
| Myeloma | Multiple Myeloma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Enteral Nutrition | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Patients under the protocol of Enteral Nutrition
- description
- Patients put under the protocol of Enteral Nutrition adapted to the conditioning autograft (BEAM or Melphalan 200)
- interventionNames
- Dietary Supplement: Enteral Nutrition
Primary outcomes (1)
- measure
- Success rate of enteral feeding
- timeFrame
- From admission to recovery from aplasia (or transfer to the intensive care unit or death)
- description
- Enteral Nutrition will be considered as a success if : TEI / ER \> 70%. On average until recovery from aplasia (or transfer to the intensive care unit or death). TEI : Total Energy Intake (per-os + enteral nutrition + glucose solutions) ER : Energy Requirement (assessed patient needs)
Secondary outcomes (10)
- measure
- Causes of failure of enteral nutrition
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patient with lymphoma or myeloma * Patient admitted for therapeutic intensification with autologous hematopoietic cells who are eligible for nutritional support by enteral nutrition * Free, informed and written consent signed by the patient Exclusion Criteria: * Refusal of the enteral nutrition * All patients with absolute or enteral nutrition contraindications: * Digestive fistula * Intestinal obstruction * Intestinal ischemia * Active digestive bleeding * Digestive malabsorption (short hail syndrome, bariatric surgery, gastrectomy) * Trauma to the base of the skull or significant deviation of the nasal septum not allowing the insertion of an naso gastric probe. * Esophagitis or barrett's esophagus * Persistent gastro-duodenal dysfunction (gastroparesis) * Patients admitted for autograft for the treatment of conditions other than lymphoma or myeloma (e. g. solid tumours or leukaemia)
References
Publications (0)
Data not yet available