Clinical trial · Interventional
Application of Platelet-rich Plasma in Pilonidal Sinus Disease
Application of Platelet-rich Plasma for the Management of Pilonidal Sinus Disease: A Randomized Clinical Trial of Different Treatment Modalities
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Pilonidal sinus disease is a common health-care problem, and surgical excision is the standard treatment modality. Controversy still exists regarding the best surgical technique for treating pilonidal disease in terms of minimizing disease recurrence and patient discomfort. In this study, the investigators compared the impact of autologous platelet-rich plasma (PRP) with that of minimally invasive techniques on pain reduction, return to daily activities, quality of life, and duration of wound healing after open excision and secondary closure.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pain | — | UNRESOLVED | — |
| Pilonidal Disease | — | UNRESOLVED | — |
| Pilonidal Sinus | — | UNRESOLVED | — |
| Quality of Life | — | UNRESOLVED | — |
| Wound Heal | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Minimal invasive surgery | Procedure | — | UNRESOLVED |
| Open surgery | Procedure | — | UNRESOLVED |
| Platelet rich plasma administration | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- PLACEBO_COMPARATOR
- label
- Group A
- description
- The open surgical method and a moist gauze (with saline) were applied to patients in group A
- interventionNames
- Procedure: Open surgery
- type
- EXPERIMENTAL
- label
- Group B
- description
- Open surgery and then PRP application were performed on patients in group B. After the cavity was filled with PRP, the wound was covered with a dry gauze.
- interventionNames
- Procedure: Open surgery
- Other: Platelet rich plasma administration
- type
- EXPERIMENTAL
- label
- Group C
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * chronic pilonial sinus disease * patients who had undergone abscess drainage and remained diseased after 8-10 weeks of drainage Exclusion Criteria: * patients with acute abscess * patients with anemia * patients that use immunosuppressive drugs * patients with haematological malignancy * patients with bleeding disorder * patients with recurrent pilonida sinus disease
References
Publications (1)
- DERIVEDBoztug CY, Karaagac Akyol T, Benlice C, Koc MA, Doganay Erdogan B, Ozcebe OI, Kuzu MA, Akyol C. Platelet-rich plasma treatment improves postoperative recovery in patients with pilonidal sinus disease: a randomized controlled clinical trial. BMC Surg. 2021 Oct 21;21(1):373. doi: 10.1186/s12893-021-01370-5. PMID 34670534