Clinical trial · Observational
Research of Pathological Imaging Diagnosis of Ocular Tumors Based on New Artificial Intelligence Algorithm
NCT04695015CI-TRIAL-00049256unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to establish a standardized process for obtaining digital pathological image information of ocular tumors; use modern pathological techniques to obtain the co-expression information of multiple biomarkers in the pathological tissues of ocular tumors, and finally construct standardized digital ocular tumors with biomarkers Pathology image database.
Conditions
Conditions (7)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Basal Cell Carcinoma | Basal Cell Carcinoma | ONTOLOGY_EXACT | 0.90 |
| Melanoma in Situ | Melanoma In Situ | ONTOLOGY_EXACT | 0.98 |
| Melanoma (Skin) | Melanoma | ONTOLOGY_EXACT | 0.85 |
| Nevus Eye | — | UNRESOLVED | — |
| Ocular Tumor | Eye Neoplasm | ALIAS | 0.90 |
| Sebaceous Gland Carcinoma of the Eyelid | Eyelid Sebaceous Gland Carcinoma | ALIAS | 0.90 |
| Squamous Cell Carcinoma in Situ | Squamous Cell Carcinoma In Situ | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (2)
- label
- Melanoma and Nevus
- description
- Patients diagnosed with melanoma or/and nevus on the skin around the eye before surgery.
- label
- Basal cell carcinoma;Squamous cell carcinoma;Sebaceous gland carcinoma
- description
- Patients diagnosed with basal cell carcinoma, squamous cell carcinoma, sebaceous gland carcinoma before surgery.
Primary outcomes (1)
- measure
- To compare the diagnostic accuracy of OPAL and IHC for melanoma and other tumors.
- timeFrame
- Up to 24 weeks.
- description
- The result of OPAL automatic analysis will be compared with IHC manual counting analysis.The accuracy of the study will be declared "success" if OPAL automatic analysis meet more than 85% of the manual count for all antibody.
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: 1. Patients diagnosed with eye tumors and undergoing eye tumor surgery. 2. Patients sign informed consent for sample collection and sample transfer agreement, and can cooperate with long-term regular follow-up requirements. Exclusion Criteria: 1. Patients who are unable to undergo tumor surgery or retain samples due to various reasons . 2. Patients who are positive for hepatitis B, HIV, and syphilis. 3. Patient compliance is poor.
References
Publications (0)
Data not yet available
No reference posted for this study.