Clinical trial · Interventional
Desflurane and Brain Relaxation in Craniotomy
Comparison of Desflurane and Propofol for Brain Relaxation in Patients Undergoing Supratentorial Craniotomy：a Randomized Controlled Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Optional brain relaxation improves the surgeon's operating conditions and is likely to minimize the degree of retraction injury ,with the potential for providing patients with a better outcome. The choice of anesthetic drugs can affect intraoperative brain relaxation. Propofol suppresses brain metabolism, reduces cerebral blood flow, and provides satisfactory brain relaxation. Desflurane is often criticized in neurosurgery due to its cerebral vasodilation and potential to increase intracranial pressure, however, it has been found to have a little clinical significance. This study intends to compare the effects of desflurane with propofol on brain relaxation in patients with supratentorial tumors under mild hyperventilation, and to provide new clinical evidence for the use of desflurane in neurosurgical anesthesia.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Supratentorial Tumor | Supratentorial Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Desflurane | Drug | — | UNRESOLVED |
| Propofol | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Desflurane inhalational anesthesia
- interventionNames
- Drug: Desflurane
- type
- ACTIVE_COMPARATOR
- label
- Propofol total intravenous anesthesia
- interventionNames
- Drug: Propofol
Primary outcomes (1)
- measure
- Proportion of satisfactory brain relaxation
- timeFrame
- during surgery
- description
- Assessed by the neurosurgeon using a 4-point scale (1= perfectly relaxed, 2= satisfactorily relaxed, 3= firm brain, 4=bulging brain) at the opening of the dura mater, score 1 and 2 represent satisfactory brain relaxation
Secondary outcomes (9)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: * 18-60 years * Scheduled for elective craniotomy for supratentorial cerebral tumors * ASA status I-III * Glasgow score of 15 * No clinical signs of intracranial hypertension * Preoperative brain imaging (CT or MRI) with midline shift less than 5mm * Informed consent signed by patients Exclusion Criteria: * Scheduled intraoperative motor evoked potential monitoring * Patients with cerebral vascular diseases * Uncontrolled cardiopulmonary disease * Schedule to retain tracheal intubation after surgery * Unable to comprehend and cooperate with the examination * BMI \> 30 Kg/m-2 * Emergency surgery * History of related anesthetic allergy
References
Publications (1)
- DERIVEDJiang Z, Wu Y, Liang F, Jian M, Liu H, Mei H, Han R. Brain relaxation using desflurane anesthesia and total intravenous anesthesia in patients undergoing craniotomy for supratentorial tumors: a randomized controlled study. BMC Anesthesiol. 2023 Jan 10;23(1):15. doi: 10.1186/s12871-023-01970-z. PMID 36624384