Clinical trial · Observational
Impact of Platinum-based Cancer Treatment on Endothelial Function
The Effect of Polychemotherapy on Endothelial Function Ans Vessel Age in Cancer Patients.
NCT04681560CI-TRIAL-00049099completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In this research we investigate endothelial function in cancer patients who received platinum based chemotherapy.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cardiovascular Complication | — | UNRESOLVED | — |
| High Blood Pressure | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (3)
- measure
- Evaluation of blood pressure
- timeFrame
- Before start of chemotherapy (1 hour after including in the trial)
- description
- Both systolic and diastiolic blood pressure were measured in the office in the seated position, noninvasively.
- measure
- Evaluation of flow-mediated vasodilation and pulse-wave velocity
- timeFrame
- Before start of chemotherapy (1 hour after including in the trial)
- description
- Flow-mediated dilatation and pulse-wave velocity were measured via "Angioscan" apparatus in the seated position.The cuff inflation period of 5 min was initially decided to produce adequate hyperaemia to allow flow-mediated dilatation. The scanning period used in our trial was 1 minite before and 9 minutes after the cuff deflation.
- measure
- Evaluation of concetration of ENOS and Big Endothelin in blood sampling
- timeFrame
- Before start of chemotherapy (1 hour after including in the trial)
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Subject has solid cancer * Subject is expected to start chemotherapy Exclusion Criteria: * Pregnancy and lactation * Severe impaired kidney function * Severe hepatic impairment * Mental disease * Acute myocardial infarction 28 days ago or earlier * Acute Cerebrovascular Event 1 month ago or earlier * Rhythm disturbance that complicate pulse wave velocity evaluation
References
Publications (0)
Data not yet available
No reference posted for this study.