Clinical trial · Interventional
Comparison of Anesthesia Effects of Sevoflurane and Propofol Combined With Dexmedetomidine in Intraoperative Neuromonitoring During Thyroidectomy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
According to the previous studies, it is reported that the use of sevoflurane in the maintenance of anesthesia may lead to delayed occurrence of positive electromyographic (EMG) signal and lower obtained signal amplitude. In this study, the investigators aimed to investigate the anesthetic effect of sevoflurane combined with dexmedetomidine for neuromonitoring during thyroid surgery. The investigators hypothesize that sevoflurane combined with dexmedetomidine can reduce the movement or spontaneous activity of vocal cords in patients and without affecting the EMG signals.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thyroid Nodule | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Anesthesia was maintained with propofol | Drug | — | UNRESOLVED |
| Anesthesia was maintained with sevoflurane | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Group DS
- description
- Anesthesia was maintained with sevoflurane and target-controlled infusion of remifentanil in the group DS
- interventionNames
- Drug: Anesthesia was maintained with sevoflurane
- type
- ACTIVE_COMPARATOR
- label
- Group DP
- description
- Anesthesia was maintained with propofol and target-controlled infusion of remifentanil in the group DP
- interventionNames
- Drug: Anesthesia was maintained with propofol
Primary outcomes (1)
- measure
- The times of movements or the times of spontaneous vocal cords activities
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * patients scheduled for thyroidectomy under general anesthesia * American Society of Anesthesiologists (ASA) grade of I or II * aged 18 to 65 years * body mass index (BMI) \< 32 kg/m2. Exclusion Criteria: * patients with RLN or vagus nerve injury were identified preoperatively * severe cardiovascular, pulmonary, liver and kidney diseases * history of allergy to narcotic include rocuronium -pregnancy or lactation- * history or current usage of medication which may interfere neuromuscular transmission; * family or personal history of malignant hyperthermia * myasthenia gravis * potential risk of airway difficulty * unable to cooperate.
References
Publications (0)
Data not yet available