Clinical trial · Interventional
Defining the Severe Paediatric Asthma Endotype
Defining the Severe Paediatric Asthma Endotype: an Integrated Approach Combining Phenotypic Analyses Related to Immune, Metabolomics and Microbial Features
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The primary objective of this project is to extensively characterize the endotypes of pre-schoolers (0 to 6 years) and school-age children (6 to 12 years) with SA using an integrated approach, combining a description of their phenotype (asthma symptoms, atopy, and lung function) associated with histological (airway inflammation and remodelling), immune (innate and adaptive immunity), metabolomics, and microbiota analyses. This goal shall be achieved by an unsupervised in-depth analysis of patients requiring bronchial endoscopy, with bronchial alveolar lavage (BAL) and bronchial biopsy, as part of their clinical assessment.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Severe Asthma | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood collection | Other | — | UNRESOLVED |
| Nasal | Other | — | UNRESOLVED |
| Saliva sample | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- OTHER
- label
- Cases with SA, classified by age group
- description
- Patient hospitalized for assessment of severe asthma
- interventionNames
- Other: Blood collection
- Other: Saliva sample
- Other: Nasal
- type
- OTHER
- label
- Controls among children w/ SA: frequent&infrequent exacerbators
- description
- Frequent exacerbators have 2 or more asthma severe exacerbations in the past years
- interventionNames
- Other: Blood collection
- Other: Saliva sample
- Other: Nasal
Primary outcomes (14)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Maximum age
- 12 Years
Show eligibility criteria text
Patient Inclusion Criteria: * Minors aged 0 to 6 years or 6 to 12 years, hospitalized for assessment of Severe Asthma * Minors need with his follow-up an bronchial endoscopy with realization of LBA and biopsies of bronchial mucosa * Social insurance affiliation, except AME * Parents or legal guardians signed the Informed consent form Control Inclusion Criteria: * Minors aged 0 to 6 years or 6 to 12 years, hospitalized for assessment of severe respiratory syndrome except severe asthma * Minors need with his follow-up an bronchial endoscopy with realization of LBA and biopsies of bronchial mucosa * Social insurance affiliation, except AME * Parents or legal guardians signed the Informed consent form Patient Exclusion Criteria * Prematurity (\<37 weeks gestation) * Broncho-pulmonary dysplasia, immune deficits, non-Severe Asthma bronchopathies, cystic fibrosis, heart disease, ongoing biotherapy
References
Publications (0)
Data not yet available