Clinical trial · Observational
Lung Ultrasound to Assess Aeration Loss After Lung Resection Surgery
Lung Ultrasound Assessment of Aeration Changes After Lung Resection Surgery: A Pilot Study
NCT04677309CI-TRIAL-00115324THORUScompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this prospective observational study is to assess perioperative changes in lung aeration after lung resection surgery using lung ultrasound, and to explore their relationship with oxygenation, inflammatory biomarkers, cardiac stress markers and diaphragmatic function.
Conditions
Conditions (8)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Lung Neoplasm | Lung Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Lung Resection Surgery | — | UNRESOLVED | — |
| Lung Ultrasound | — | UNRESOLVED | — |
| Lung Ultrasound Score | — | UNRESOLVED | — |
| One-lung Ventilation (OLV) | — | UNRESOLVED | — |
| Postoperative Pulmonary Complications (PPCs) | — | UNRESOLVED | — |
| Thoracic Surgery | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Perioperative lung ultrasound assessment | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Lung resection surgery
- description
- Adult patients scheduled for elective lobectomy surgery under one-lung ventilation in a tertiary referral hospital.
- interventionNames
- Diagnostic Test: Perioperative lung ultrasound assessment
Primary outcomes (1)
- measure
- Change in lung aeration after lung resection surgery assessed by lung ultrasound score
- timeFrame
- preoperative vs immediate postoperative period vs 24 hours after surgery
- description
- The lung ultrasound score is a semiquantitative score used to assess lung aeration. Higher values indicate greater loss of aeration. Changes will be assessed between the preoperative period, the immediate postoperative period after extubation, and 24 hours after surgery.
Secondary outcomes (5)
- measure
- Regional distribution of lung ultrasound findings in the operated and non-operated lung
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age \> 18 * ASA I-III * Non-small cell lung neoplasm * Elective lobectomy * Under one-lung ventilation Exclusion Criteria: * pregnancy * Diagnosed pulmonary fibrosis * Scheduled surgery limited to biopsy * Surgery that includes resection of the thoracic wall or the diaphragm * Predicted FEV1 \< 40% * Neoplasm metastasis * Obesity class II or more (BMI ≥ 35 kg/m\^2) * Risk of malnutrition CONUT score \> 1 * Hemoglobin \< 10 g/dl * Chronic kidney failure: glomerular filtration \< 60 ml/min/m\^2, nephrectomy, kidney transplantation * Treatment with corticosteroids or immunosuppressive agents 3 months before surgery * Transfusion of blood products during the previous 10 days * Heart failure (New York Heart Association Functional Class 3 or 4) during the week before surgery. * Heart valve diseases over stage B of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines 2014 * Previously documented elevated left atrial pressure or cardiac disease associated with elevated left-sided filling pressures.
References
Publications (0)
Data not yet available
No reference posted for this study.