SHR7390 in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer

Inclusion Criteria:

* Patients aged 18-75 years，male
* ECOG PS：0-1
* Life expectancy of more than 6 months
* After surgery or drug castration, testosterone level was \< 50 ng / dl. For subject receiving LHRH agonist / antagonist therapy (patients without orchiectomy), the treatment must start at least 4 weeks before the first day of cycle 1 and must be continued throughout the study
* Failure (radiological or PSA progression) or intolerance of at least one but not more than two taxanes based chemotherapy regimens and novel endocrine therapy (at least one of enzalutamide, apartamide, abitelone or shr3680). If docetaxel regimen used more than once, count as one regimen
* Disease progressed within 6 months prior to inclusion in the study. Disease progression defined as the occurrence of one or more of the following three items at the same time of castration：

  ① PSA progression，defined as at least twice increases in PSA level (interval time ≥ 1 week, and PSA level at screening should be ≥ 2ng / ml)

  ②Disease progression as defined in RECIST 1.1

  ③Bone disease progression defined by PCWG3，more than 2 new lesions in bone scan
* Metastatic lesions with radiologica evidence， measurable non-bone target lesions
* Adequate hepatic, renal, heart, and hematologic functions (no blood transfusion or hematopoietic growth factor treatment within 2 weeks before blood routine screening)：platelets\>80×10\^9/L，neutrophil\>1.5×10\^9/L, Hb≥90 g/L,total bilirubin≤1.5×limit of normal(ULN), ALT and AST ≤2.5×ULN（≤5×ULN with liver metastasis），blood urea nitrogen and creatinine≤1.5×ULN
* Willingness and ability to comply with scheduled visits, treatment plans, laboratory tests, and other study procedure
* Willing to participate in this clinical trial, understand the research procedures and have signed informed consent

Exclusion Criteria:

* Prior treatment with MEK inhibitors，including trametinib
* Washout period from the end of any previous anti-tumor treatment (including radiotherapy, chemotherapy, surgery, molecular targeted therapy, immunotherapy, androgen receptor inhibitors, CYP-17 inhibitors, 5 α-reductase inhibitors, estrogen, progesterone drugs, etc) to the first administration of the study drug less than 1 week (bicalutamide elution period \< 2 weeks)
* Plant drugs (e.g. Saw Palmetto) or steroids that may reduce PSA levels within 4 weeks, or planned to be used during the trial period (except for temporary steroid drugs for preventing or treating allergies)
* Plan to receive any other anti-tumor treatment during this trial
* Last drug administration from other clinical trials within 4 weeks
* Radiological confirmed tumor foci in the brain
* Severe bone injury caused by tumor bone metastasis judged by researchers, including severe bone pain with poor control, pathological fracture of important parts and spinal cord compression occurred or expected to occur in recent 6 months
* History of epilepsy, or the disease that can induce epilepsy within 12 months (including the history of transient ischemic attack, cerebral apoplexy (except for cerebral ischemic foci simply found by imaging examination), brain trauma with disturbance of consciousness and hospitalization）
* Hypotension (systolic blood pressure \< 86mmhg) or uncontrollable hypertension (systolic blood pressure ≥ 150mmhg or diastolic blood pressure ≥ 100mmhg) within 30 days. The blood pressure results were the average value of three consecutive measurements with an interval of more than 2 minutes
* Active heart disease including severe/unstable angina pectoris, myocardial infarction, symptomatic congestive heart failure, and ventricular arrhythmias requiring drug treatment within 6 months
* Inability to swallow, chronic diarrhea and intestinal obstruction, or other factors affecting drug administration and absorption
* History of retinopathy confirmed by ophthalmic examination or neurosensory retinal detachment. Risk factors such as retinal vein thrombosis / occlusion (RVO), central serous retinopathy (CSR) or neovascular macular degeneration
* IOP \> 21mmhg or diagnosed with glaucoma within 4 weeks
* Active HBV or HCV infection (HBV copies ≥ 10\^4 copies / ml, HCV copies ≥ 10\^3 copies/ml)
* History of immunodeficiency (including HIV positive, other acquired and congenital immunodeficiency diseases) or organ transplantation history
* Not willing to take effective contraceptive measures during the whole study period and within 6 months after the last administration
* Any accompanying diseases (such as poorly controlled hypertension, severe diabetes, thyroid disease and psychosis) that seriously endanger the safety of patients or affect the patients to complete the study