Clinical trial · Observational
Host RNA Signature in Children With Cancer and Infection
Host RNA Signature to Discriminate Bacterial From Viral Infection and Non-specific Inflammation in Children With Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim is to investigate if RNA expression signature can discriminate bacterial from viral infection or non-infectious inflammation in children with cancer. Earlier studies in immunocompetent children have shown promising results, but studies in immunocompromised children are lacking. We aim to include 300 febrile episodes in children with cancer. The samples will be analysed by RNA sequencing. If succesfull, this method can help prevent unnecessary antibiotic treatment, reduce hospital admissions, side effects and antimicrobial resistance and improve quality of life for children during cancer treatment.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Childhood Cancer | Childhood Malignant Neoplasm | ALIAS | 0.90 |
| Infection | — | UNRESOLVED | — |
| Neutropenia, Febrile | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| RNA expression signature | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Group 1
- description
- 70 children with cancer and a positive blood culture.
- interventionNames
- Diagnostic Test: RNA expression signature
- label
- Group 2
- description
- 50 children with cancer and no positive blood culture.
- interventionNames
- Diagnostic Test: RNA expression signature
Primary outcomes (1)
- measure
- RNA signature
- timeFrame
- 1.5 years
- description
- To detect specific RNA signatures in whole blood in children with febrile neutropenia
Secondary outcomes (4)
Eligibility
Eligibility (as posted)
- Sex
- All
- Maximum age
- 17 Years
Show eligibility criteria text
Inclusion Criteria: Children with cancer and fever. Fever defined as temperature above 38.5 °C measured once, or 38.0-38.5 °C for ≥ 1 hour. Exclusion Criteria: The children can be excluded if they turn out to have a different diagnosis than expected or if it is not possible to draw the blood tests.
References
Publications (0)
Data not yet available