Clinical trial · Interventional
Improvement of Care of Patients Undergoing Pancreaticoduodenectomy
NCT04668781CI-TRIAL-00087244completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The study is a randomised controlled trial comparing the effectivity and impact of epidural analgesia and wound catheter analgesia in patients undergoing pancreaticoduodenectomy. The aim of the study is to examine whether there are a difference in perioperative fluid therapy and complication rates between the patients in epidural and wound catheter groups.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreas Cancer | Pancreatic Carcinoma | ALIAS | 0.90 |
| Pancreatic Diseases | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Analgesia via epidural catheter | Procedure | — | UNRESOLVED |
| Analgesia via wound catheter | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Epidural analgesia
- interventionNames
- Procedure: Analgesia via epidural catheter
- type
- EXPERIMENTAL
- label
- Wound catheter analgesia
- interventionNames
- Procedure: Analgesia via wound catheter
Primary outcomes (1)
- measure
- The norepinephrine consumption
- timeFrame
- Postoperative day 0
- description
- Norepinephrine consumption on POD 0
Secondary outcomes (7)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: * age 18 years or over * patients who undergo pancreaticoduodenectomy Exclusion Criteria: * patients to whom are made a major vascular reconstruction * patients with significant comorbidities and inability to use PCA * regural use of strong opioids or drugs preoperatively * patients with severe chronic pain issues * chronic atrial fibrillation * patients who refuse to take part to the study
References
Publications (1)
- DERIVEDPeltoniemi PM, Nieminen TM, Belfrage HIS, Ylikoski EK, Kokkola AJ, Koivunen RI, Mustonen HK, Pere PJ, Seppanen HE. Impact of epidural versus wound catheter analgesia for patients undergoing open pancreatoduodenectomy: A randomized controlled trial. Pancreatology. 2026 Jul 7:S1424-3903(26)00231-0. doi: 10.1016/j.pan.2026.07.003. Online ahead of print. PMID 42436052