Clinical trial · Interventional
Dexamethasone for Post Uterine Artery Embolization Pain
Intra-Arterial Dexamethasone for the Alleviation of Pain and Postembolization Syndrome Following Uterine Artery Embolization
NCT04655144CI-TRIAL-00100358Dex-FibcompletedPhase 3Results postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this research is to investigate if administration steroids (anti-inflammatory medication) via the uterine arteries during uterine fibroid embolization (A non surgical procedure for treating uterine fibroids by blocking their blood supply) can help reduce the pain, nausea, vomiting, and general feeling of weakness following the procedure.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Leiomyoma | Leiomyoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dexamethasone | Drug | Dexamethasone | ALIAS |
| Saline | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Dexamethasone Arm
- description
- A total of 5mg dexamethasone will be administered into each uterine artery (10mg total) prior to uterine artery embolization.
- interventionNames
- Drug: Dexamethasone
- type
- PLACEBO_COMPARATOR
- label
- Saline Arm
- description
- A volume of normal saline, equal to the total volume delivered in the Dexamethasone Arm, will be administered into each uterine artery prior to uterine artery embolization.
- interventionNames
- Drug: Saline
Primary outcomes (1)
- measure
- Pain Scores Using the VAS Questionnaire
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 20 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Women who meet criteria to undergo uterine fibroid embolization for symptomatic fibroids. Exclusion Criteria: * Currently pregnant or actively attempting to conceive * Those deemed mentally impaired to make their own medical decisions * Previous documented allergy to dexamethasone * Those currently taking daily steroids for any reason * Those with diabetes or deemed to be pre-diabetic * Those with contraindications for angiography * Prisoners
References
Publications (1)
- DERIVEDBriley K Jr, Reddy R, Cavada A, Alessandrino F, Zarnegarnia Y, Carugno J, Miller Z, Venkat S, Allakhverdieva EA, Mohan P. Intraarterial Dexamethasone for Pain Relief After Uterine Fibroid Embolization: A Randomized Clinical Trial. JAMA Netw Open. 2026 Jul 1;9(7):e2625004. doi: 10.1001/jamanetworkopen.2026.25004. PMID 42507444