Clinical trial · Observational
Colorectal Cancer in Crohn's Disease
Colorectal Cancer in Crohn's Disease: Long Term Outcomes of Different Surgical Procedures
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Retrospective multicentre study. All patients with a diagnosis of Crohn's disease (CD) and operated for colorectal cancer (CRC) between 01/01/2010 and 01/01/2020 will be included in the dataset. Data will include preoperative, intraoperative and postoperative variables, with long term follow up when feasible. The study will focus on a comparison between patients treated with total proctocolectomy (TPC) and patients treated with subtotal colectomy (STC) or segmental resection (SR). Primary endpoints will be oncologic outcomes, postoperative morbidity and mortality. Secondary endpoints include quality of life (QoL).
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Crohn Disease | — | UNRESOLVED | — |
| Inflammatory Bowel Diseases | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Segmental colectomy | Procedure | — | UNRESOLVED |
| Total colectomy | Procedure | — | UNRESOLVED |
| Total proctocolectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Chron's disease patients with colorectal cancer
- description
- This group of patients with Chron's disease have been diagnosed with colorectal cancer and treated surgically
- interventionNames
- Procedure: Total proctocolectomy
- Procedure: Total colectomy
- Procedure: Segmental colectomy
Primary outcomes (2)
- measure
- Overall Survival
- timeFrame
- 5 years
- description
- percentage of patients alive
- measure
- disease free survival
- timeFrame
- 5 years
- description
- percentage of patients disease free
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * All patients with a diagnosis of Crohn's disease and concomitant primary colorectal cancer who underwent surgery in an expert centre between 01/01/2010 and 01/01/2020 Exclusion Criteria: * Patients who underwent non-oncologic segmental resection will be excluded from outcome analysis. * Patients with known genetic colorectal cancer syndromes (eg. Familial Adenomatous Polyposis, Hereditary Non-Polyposis ColoRectal Cancer Syndrome)
References
Publications (0)
Data not yet available