Clinical trial · Observational
Immune Checkpoints in COPD
Predictive Role of Immune Checkpoints in COPD Evolution Towards Lung Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this study is to investigate the mechanisms underlying the complex interaction between Chronic obstructive pulmonary disease (COPD) and lung cancer. Therefore, in order to identify a possible role of immune checkpoints not only in the susceptibility to COPD development but also in its evolution towards lung cancer, will be evaluate the correlation between PD-L1 expression and cigarette smoke exposure in COPD patients. Although there are many epidemiological studies highlighting the interconnections between COPD and lung cancer and the influence of cigarette smoke, the molecular bases of this association are less well defined. Initially they were thought to be driven just by innate inflammation, however, recent studies have also demonstrated the influence of the adaptive immune system. Despite this, the role of immune checkpoints in chronic lung inflammatory diseases such as COPD is less well understood. COPD is currently the 4th leading cause of death worldwide but is assessed to be the 3rd by the end of 2020 resulting in an economic and social burden that is in continuous progression.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Asthma | — | UNRESOLVED | — |
| Copd | — | UNRESOLVED | — |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Severe ARDS | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| check immune check points | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- Healthy never smokers
- description
- Clinical evaluation of immune check points expression. A prospective study
- interventionNames
- Other: check immune check points
- label
- Smokers with normal lung function
- description
- evaluation of immune check points expression
- interventionNames
- Other: check immune check points
- label
- Lung cancer
- description
- evaluation of immune check points expression
- interventionNames
- Other: check immune check points
- label
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * • over 18 years of age with suspected diagnosis of pulmonary neoplasia * signed the informed consent Exclusion Criteria: * • infected diseases * interstitiopathy * asthma, * autoimmune diseases, * neoplasia other than inclusion criteria * subjects on glucocorticoid therapy * alcohol consumption (\>3 alcoholic beverages daily) * substance abuse * inability to give written informed consent * those who will not sign the consent to the processing of personal data
References
Publications (0)
Data not yet available