Clinical trial · Interventional
Functional Outcomes of Knee Protheses for Malignant Tumours of Bone
Clinical Results, Isokinetic Analysis and Radiologic Outcomes of Knee MUTARS Protheses Replacement for Malignant Tumours of Bone
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The placement of mega knee prosthesis is a necessity after a large tumor resection and oncological. These mega knee prostheses implanted in the context of oncological surgery have been very few evaluated in the literature. Active knee extension is essential in order to walk properly. The study propose the evaluation of this prosthesis by checking the possibility of locking of the prosthetic joint and thus the possibility of active walking. A more in-depth, isokinetic analysis at 1 year of follow-up will also be done in an exploratory manner, as the literature has no data on this subject.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bone Cancer | Malignant Bone Neoplasm | ALIAS | 0.90 |
| Knee Disease | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| MUTARS® modular reconstruction prostheses | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- case group
- description
- Patients with knee bone malignancy
- interventionNames
- Procedure: MUTARS® modular reconstruction prostheses
Primary outcomes (1)
- measure
- Rate of patients with active locking of the operated knee
- timeFrame
- Baseline
- description
- rate of patients with successful locking will be estimated by the frequency observed Active locking of the operated knee
Secondary outcomes (9)
- measure
- Measurement of joint amplitudes
- timeFrame
- Baseline
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patient with MUTARS® modular reconstruction prostheses following primary or secondary knee bone malignancy with minimal follow-up of one year, * Cardiological follow-up including at least one ECG and a clinical examination of less than 1 year (ability to perform the isokinetic test), * Written informed consent from patient, * Socially insured patient, * Patient willing to comply with all study procedures and study duration. Exclusion Criteria: * \- Underage, * Less than a one-year follow-up after surgery (stability of results is not achieved if follow-up is less than one year), * Meniscal lesion knee healthy side, * Prosthetic surgery of the knee healthy side, * Patient with an unbound fracture, * Patient without cardiological follow-up, * Pregnant or breastfeeding woman, * Inability to receive information, consent and participate in the whole study, * No social insurance cover, * No written consent, * Person under judicial protection or deprived of liberty.
References
Publications (1)
- RESULTRodrigues V, Szymanski C, Saab M, Maynou C, Tiffreau V, Wieczorek V, Dartus J, Amouyel T. Recovery of leg strength based on isokinetic testing after tumor resection and reconstruction with a modular rotating hinge knee system: Prospective cross-sectional study with a minimum follow-up of 24 months. Orthop Traumatol Surg Res. 2023 Nov;109(7):103631. doi: 10.1016/j.otsr.2023.103631. Epub 2023 Apr 28. PMID 37119875