Clinical trial · Interventional
Managing Cancer and Living Meaningfully
Managing Cancer and Living Meaningfully (CALM) in Primary Brain Tumor Patients
NCT04646213CI-TRIAL-00075024CALMcompletedN/AResults postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to pilot test an empirically supported psychotherapeutic intervention, Managing Cancer and Living Meaningfully (CALM). Researchers hope to better understand the potential benefits of this intervention on brain tumor patients' mood and quality of life. This may lead to improvements in doctor's understanding of how to enhance brain tumor patient's wellbeing and overall functioning.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer Brain | Brain Neoplasm | PROBABILISTIC | 0.70 |
| Mood | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Managing Cancer and Living Meaningfully (CALM) Therapy | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Therapy
- description
- psychotherapeutic intervention
- interventionNames
- Behavioral: Managing Cancer and Living Meaningfully (CALM) Therapy
Primary outcomes (10)
- measure
- Recruitment for CALM
- timeFrame
- 1 day
- description
- Number of potential participants consented and enrolled
- measure
- Completion of CALM Sessions
- timeFrame
- 3 months
- description
- Number of participants completing CALM sessions
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * have a confirmed malignant brain cancer diagnosis via histopathology * be a minimum of 2 weeks post-surgical resection or biopsy (if applicable) * be primarily English speaking * be age 18-89 * obtain \>20 on the Telephone Interview for Cognitive Status (TICS) * have current elevated depression or death anxiety symptoms * have a reliable internet connection to participate in the Zoom therapy sessions Exclusion Criteria: * Major communication difficulties as determined by the research team which would prohibit psychotherapeutic interaction * inability to meet with interventionist via an electronic device for telehealth intervention sessions * inability to provide informed consent
References
Publications (1)
- DERIVEDLoughan AR, Willis KD, Braun SE, Rodin G, Lanoye A, Davies AE, Svikis D, Mazzeo S, Malkin M, Thacker L. Managing cancer and living meaningfully (CALM) in adults with malignant glioma: a proof-of-concept phase IIa trial. J Neurooncol. 2022 May;157(3):447-456. doi: 10.1007/s11060-022-03988-8. Epub 2022 Apr 18. PMID 35437687