Clinical trial · Observational
Nitrates and IL-8 in Barrett's Esophagus
The Association Between Nitrates, Nitrosylated Proteins, and Interleukin-8 in Barrett's Esophagus and Esophageal Adenocarcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): could not collect adequate samples
Summary
Brief summary (as posted)
The purpose of this study is to determine if nitrates and IL-8 (which are found in food and throughout the body regulating stomach acidity) play a role in Barrett's Esophagus and/or Esophageal Adenocarcinoma severity and if screening for these biomarkers can help predict patients that are more at risk for developing worsening disease.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Barrett Esophagus | — | UNRESOLVED | — |
| Esophageal Adenocarcinoma | Esophageal Adenocarcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (7)
- label
- Group 1-NSE
- description
- Patients found to have grossly normal squamous epithelium during endoscopy
- label
- Group 2-EEG
- description
- Patients found to have grossly apparent erosive esophagitis \>1cm with Los Angeles Classification A-D
- label
- Group 3-NDBE Short
- description
- Patients with non-dysplastic Barrett's Esophagus (NDBE) \> 1cm (Short Segment)
- label
- Group 4-NDBE Long
- description
- Patients with non-dysplastic Barrett's Esophagus (NDBE) \> 1cm (Long Segment)
- label
- Group 5
- description
- Barrett's Esophagus (BE) with high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: \- Patients undergoing a clinicallly-indicated Esophagogastroduoedoscopy (EGD). Exclusion Criteria: * Comorbid inflammatory medical condition. * Use of antiinflammatory (aspirin and NSAIDs) or immunosuppressants over the past 1 week. * Use of nitrate containing medication in the past 1 week. * Consumption of nitrate rich foods in preceding 24 hours. * Known allergy to meat or nitrates
References
Publications (0)
Data not yet available