Yangzheng Compound Mixture in the Treatment of Sleep Disorder in Cancer Patients

Inclusion Criteria:

* Age ≥18;
* Histologically or cytologically confirmed as malignant tumor;
* Receiving chemotherapy or a combination of chemotherapy;
* The syndrome differentiation of traditional Chinese medicine is the Qi-yin deficiency syndrome;
* Sleep disorders were diagnosed by investigators and the Pittsburgh Sleep Quality Index (PSQI) score was ≥ 8;
* The date of diagnosis of sleep disorder is later than the date of the first diagnosis of cancer. Or patients with sleep disorders for a long time receiving regular treatment，sleep disorders aggravated after cancer diagnosis or chemotherapy;
* Pain has been controlled well \[patients were being treated with analgesics regularly，numerical rating scale（NRS） score ≤ 3\];
* The participant must be able to read and express themselves clearly, can communicate with investigators and cooperate in completing the questionnaire;
* Participants voluntarily join the study with good compliance, and are willing to sign a written informed consent document;
* Survival period will be longer than 6 months.

Exclusion Criteria:

* Pregnant or lactating women;
* Allergic to Yangzheng Compound Mixture;
* Previous diagnosis of sleep apnea;
* The laboratory test value of liver and renal function is more than 2.5 times the upper limit of normal value;
* Symptoms of brain metastasis due to malignant tumor has not been effectively controlled;
* Participating in other drug clinical trials which did not allow to participate in this study;
* Refused to cooperate with follow-up;
* The researchers did not consider it appropriate for the patients to participate in this study for other reasons.