Clinical trial · Interventional
TIPS Combined With Microwave Ablation in HCC Patients With Refractory Ascites
Feasibility and Clinical Outcome of TIPS Combined With Subsequent Microwave Ablation in HCC Patients With Refractory Ascites
NCT04640116CI-TRIAL-00048983unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Transjugular intrahepatic portosystemic shunt (TIPS) could effectively decrease portal hypertension-related complications. This study intends to evaluate the efficacy and safety of TIPS combined with subsequent microwave ablation in HCC patients with refractory ascites.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Ascites | — | UNRESOLVED | — |
| Cirrhosis, Liver | — | UNRESOLVED | — |
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Liver Diseases | — | UNRESOLVED | — |
| Portal Hypertension | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| microwave ablation (MWA) | Procedure | — | UNRESOLVED |
| Transjugular intrahepatic portosystemic shunt (TIPS) | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- TIPS combined with microwave ablation
- interventionNames
- Procedure: Transjugular intrahepatic portosystemic shunt (TIPS)
- Procedure: microwave ablation (MWA)
Primary outcomes (1)
- measure
- overall survival (OS)
- timeFrame
- 24 months
- description
- the interval from TIPS to death or lost to follow-up
Secondary outcomes (4)
- measure
- change in Child-Pugh stage
- timeFrame
- 6 months
- description
- the liver function stage change from C to B or from B to A
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age between 18-70 years 2. Diagnosis of HCC based on the European Association for the Study of the Liver 3. Tumor diameter ≤ 3cm 4. Refractory ascites based on International Ascites Club: (a) intensive diuretics (spironolactone 400 mg/d combined with furosemide 160 mg/d) and sodium-restricted diet (\<90 mmoVd) for at least 1 week have no response; (b) lack of response to diuretic therapy; (c) early recurrence of ascites within 4 weeks; (d) Diuretic-induced complications. The grading of ascites was divided into mild ascites, moderate ascites, and large or gross ascites Exclusion Criteria: 1. Congestive heart failure or severe valvular heart failure 2. Uncontrolled systemic infection or inflammation 3. Macroscopic vascular invasion or extrahepatic metastasis 4. Severe pulmonary hypertension 5. Severe renal insufficiency (except hepatogenic renal insufficiency) (6) rapidly progressive liver failure 6. Diffuse malignant liver tumor 7. Contrast agent allergy
References
Publications (0)
Data not yet available
No reference posted for this study.