Clinical trial · Interventional
Physical Capacity in Hodgkin Lymphoma Survivors
Physical Capacity Evaluation and Effects of ExerciseTraining on Hodgkin Lymphoma Survivors
NCT04636255CI-TRIAL-00110277completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The study aims to investigate if physical capacity obtained in the cardiopulmonary exercise test can predict cardiovascular alterations in Hodgkin Lymphoma (HL) Survivors. In addition, to study the effects of exercise training on physical capacity and cardiovascular responses in these patients.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cardiovascular Diseases | — | UNRESOLVED | — |
| Chemotherapy Effect | — | UNRESOLVED | — |
| Hodgkin Lymphoma, Adult | Adult Hodgkin Lymphoma | ONTOLOGY_EXACT | 0.98 |
| Radiation Effect | — | UNRESOLVED | — |
Interventions
Interventions (9)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Assessment of Coronary Anatomy and Calcium Score | Diagnostic Test | — | UNRESOLVED |
| Assessment of Heart rate variability | Diagnostic Test | — | UNRESOLVED |
| Blood Assessments | Diagnostic Test | — | UNRESOLVED |
| Blood Pressure and Cardiac Autonomic Control | Diagnostic Test | — | UNRESOLVED |
| Cardiac Function and Structure | Diagnostic Test | — | UNRESOLVED |
| Evaluation of Baroreflex Control | Diagnostic Test | — | UNRESOLVED |
| Physical Capacity | Diagnostic Test | — | UNRESOLVED |
| Physical Characteristics | Procedure | — |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Exercise training group
- description
- Patients in the experimental group, under clinic follow up will perform combined exercise training for 16 weeks
- interventionNames
- Procedure: Physical Characteristics
- Diagnostic Test: Assessment of Heart rate variability
- Diagnostic Test: Blood Pressure and Cardiac Autonomic Control
- Diagnostic Test: Evaluation of Baroreflex Control
- Diagnostic Test: Cardiac Function and Structure
- Diagnostic Test: Assessment of Coronary Anatomy and Calcium Score
- Diagnostic Test: Blood Assessments
- Diagnostic Test: Physical Capacity
- Procedure: Physical Training
- type
- SHAM_COMPARATOR
- label
- Control Group
- description
- Patients will be only clinically followed up. They will not perform exercise training.
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Hodgkin Lymphoma Survivors * Over 18 years old * Chemotherapy with anthracycline and mediastinal radiotherapy in the last 5 years or more Exclusion Criteria: * Renal insufficiency * Pregnant women, * Iodinated contrast allergy, * Life expectancy less than 1 year.
References
Publications (13)
- BACKGROUNDAnsell SM. Hodgkin Lymphoma: Diagnosis and Treatment. Mayo Clin Proc. 2015 Nov;90(11):1574-83. doi: 10.1016/j.mayocp.2015.07.005. PMID 26541251
- BACKGROUNDHeidenreich PA, Schnittger I, Strauss HW, Vagelos RH, Lee BK, Mariscal CS, Tate DJ, Horning SJ, Hoppe RT, Hancock SL. Screening for coronary artery disease after mediastinal irradiation for Hodgkin's disease. J Clin Oncol. 2007 Jan 1;25(1):43-9. doi: 10.1200/JCO.2006.07.0805. PMID 17194904
- BACKGROUNDGilchrist SC, Barac A, Ades PA, Alfano CM, Franklin BA, Jones LW, La Gerche A, Ligibel JA, Lopez G, Madan K, Oeffinger KC, Salamone J, Scott JM, Squires RW, Thomas RJ, Treat-Jacobson DJ, Wright JS; American Heart Association Exercise, Cardiac Rehabilitation, and Secondary Prevention Committee of the Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; and Council on Peripheral Vascular Disease. Cardio-Oncology Rehabilitation to Manage Cardiovascular Outcomes in Cancer Patients and Survivors: A Scientific Statement From the American Heart Association. Circulation. 2019 May 21;139(21):e997-e1012. doi: 10.1161/CIR.0000000000000679. PMID 30955352
- BACKGROUNDGirinsky T, M'Kacher R, Lessard N, Koscielny S, Elfassy E, Raoux F, Carde P, Santos MD, Margainaud JP, Sabatier L, Ghalibafian M, Paul JF. Prospective coronary heart disease screening in asymptomatic Hodgkin lymphoma patients using coronary computed tomography angiography: results and risk factor analysis. Int J Radiat Oncol Biol Phys. 2014 May 1;89(1):59-66. doi: 10.1016/j.ijrobp.2014.01.021. Epub 2014 Mar 7. PMID 24613809
- BACKGROUNDHoppe RT, Advani RH, Ai WZ, Ambinder RF, Aoun P, Bello CM, Bierman PJ, Blum KA, Chen R, Dabaja B, Duron Y, Forero A, Gordon LI, Hernandez-Ilizaliturri FJ, Hochberg EP, Maloney DG, Mansur D, Mauch PM, Metzger M, Moore JO, Morgan D, Moskowitz CH, Poppe M, Pro B, Winter JN, Yahalom J, Sundar H; National Comprehensive Cancer Network. Hodgkin lymphoma, version 2.2012 featured updates to the NCCN guidelines. J Natl Compr Canc Netw. 2012 May;10(5):589-97. doi: 10.6004/jnccn.2012.0061.