Clinical trial · Observational
Cognitive Status After Removal of Skull Base Meningioma
Pre and Post-Operative Cognitive Status in Patients Undergoing Surgery for Resection of Meningioma Associated With the Frontal and Temporal Lobes
NCT04635657CI-TRIAL-00112299recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this prospectively enrolling trial is to assess long-term cognitive outcomes of patients undergoing surgery for resection of a meningioma associated with the frontal and temporal lobes.
Conditions
Conditions (7)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cognitive Decline | — | UNRESOLVED | — |
| Cognitive Impairment | — | UNRESOLVED | — |
| Frontal Meningioma | — | UNRESOLVED | — |
| Meningioma | Meningioma | ONTOLOGY_EXACT | 0.90 |
| Post-Surgical Cognition | — | UNRESOLVED | — |
| Skull Base Meningioma | Skull Base Meningioma | ONTOLOGY_EXACT | 0.98 |
| Temporal Meningioma | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Long-term Cognitive testing | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Meningioma Group
- description
- This group will include all patients in the study, regardless of location (frontal or temporal lobe) or surgical approach (endoscopic endonasal or craniotomy). Fifty patients will be included in the cohort
- interventionNames
- Other: Long-term Cognitive testing
Primary outcomes (1)
- measure
- Overall cognitive function
- timeFrame
- 12 months
- description
- Cognitive function will be compared at baseline and at one year post-operatively.
Secondary outcomes (2)
- measure
- Cognitive function based on surgical approach using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)
- timeFrame
- 12 months
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 89 Years
Show eligibility criteria text
Inclusion Criteria: * Subject has a meningioma associated with the frontal or temporal lobes * Subject is scheduled to undergo open craniotomy or Endoscopic Endonasal surgery * Subject is 18 years of age or older * The subject must in the investigator's opinion, be psychosocially, mentally, and physically able to fully comply with this protocol including the required follow-up visits, the filling out of required forms, and have the ability to understand and give written informed consent * Previous surgery will not exclude the patient as a new baseline cognitive evaluation will occur. Exclusion Criteria: * Patient is a prisoner * Patient is 90 years of age or older * Pregnant women * Previous radiation to the brain
References
Publications (0)
Data not yet available
No reference posted for this study.