Clinical trial · Observational
Implementation of Adjuvants in Intercostal Nerve Blockades for Thoracoscopic Surgery in Pulmonary Cancer Patients
Implementation of Adjuvants in Intercostal Nerve Blockades for Thoracoscopic Surgery in Pulmonary Cancer Patients: A Before and After Study
NCT04633850CI-TRIAL-00052509completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To investigate the effect of intercostal blockade with and without adjuvants.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Local Anesthesia | — | UNRESOLVED | — |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Nerve Block | — | UNRESOLVED | — |
| Postoperative Pain | — | UNRESOLVED | — |
| Thoracoscopic Surgery | — | UNRESOLVED | — |
| Video Assisted Thoracoscopic Surgery | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bupivacain | Drug | — | UNRESOLVED |
| Dexamethasone | Drug | Dexamethasone | ALIAS |
Design
Arms and outcomes
Arms (2)
- label
- Before implementation
- description
- Perineural bupivacaine without adjuvants.
- interventionNames
- Drug: Bupivacain
- label
- After implementation
- description
- Perineural bupivacaine with intravenous dexamethasone.
- interventionNames
- Drug: Dexamethasone
Primary outcomes (1)
- measure
- Total equipotent dose of opioids
- timeFrame
- 24 hours
- description
- Sum of equipotent opioid doses during the first 24 hours after surgery
Secondary outcomes (11)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: ° Consecutive adult patients over 18 years of age scheduled to undergo VATS because of verified/suspected lung cancer. Exclusion Criteria: * Inability to understand verbal and written information. * Preexisting chronic pain condition. * Preoperative daily treatment with pain medication (Non-opioids, opioids, gabapentin/pregabalin). * Previous thoracic surgery. * Previous chemotherapy due to thoracic malignancy and / or radiation therapy. to the thorax. * Pregnant women. * Autoimmune neuromuscular diseases (sclerosis, peripheral neuromuscular disorders). General muscle weakness or atrophy. * Hypersensitivity, allergy or intolerance to dexamethasone, bupivacaine or adrenaline. * Preoperative epidural anaesthesia.
References
Publications (1)
- DERIVEDLobel J, Danielsen AV, Sperling PK, Bisgaard J. Intravenous dexamethasone in pain treatment after video-assisted thoracoscopic surgery. Dan Med J. 2024 Feb 12;71(3):A05230317. doi: 10.61409/A05230317. PMID 38445317