Clinical trial · Observational
Genetic Investigation of Cancer Predisposition
NCT04620278CI-TRIAL-00100225not yet recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Clinical information and samples (blood, saliva, and tumor) will be collected from patients with multiple cancers and/or a family history of cancer as well as from affected and unaffected relatives; samples will be systematically sequenced and evaluated for candidate driver mutations.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Genetic Predisposition | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| DNA or RNA Sequencing | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (3)
- measure
- Identification of Rare Genetic Variant
- timeFrame
- through study completion- approximately 6-12 months
- description
- Genetic screen detects a mutation that is likely responsible for tumor development
- measure
- Identification of somatic (tumor only) mutation
- timeFrame
- through study completion- approximately 6-12 months
- description
- Genetic screen detects a mutation that is likely responsible for tumor development
- measure
- Identification of Rare Genetic Variant in family members
- timeFrame
- through study completion- approximately 6-12 months
- description
- Genetic screen detects a mutation that is likely responsible for tumor development
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: 1. Any age 2. Meets at least ONE of the following: 1. Personal history (with documented diagnosis) of cancer before the age of 50 2. Personal history of more than one primary cancer 3. Documented diagnosis of cancer AND family history of that same cancer type or multiple other cancers that do not fit classical criteria of hereditary cancer syndromes 4. Documented diagnosis of a rare cancer AND family history of rare cancers that do not fit classical criteria of hereditary cancer syndromes 5. There is the same type of cancer in several generations of a family 6. Documented diagnosis of multicentric cancers (e.g bilateral cancers in paired organs, or multifocal cancers in single organs) that usually occur as single lesions when presented sporadically 7. Early onset cancer (before the age of 50, or breast cancer before age 45) AND family history of early onset cancer Capable of providing access to detailed medical records and family history of cancer Exclusion Criteria: 1. Established genetic diagnosis of a known hereditary cancer syndrome that is compatible with the clinical presentation 2. Incarcerated
References
Publications (0)
Data not yet available
No reference posted for this study.