Clinical trial · Interventional
The Value of Lymph Node Dissection of Indocyanine Green-guided Near-infrared Fluorescent Imaging in Esophagectomy
The Value of Lymph Node Dissection of Indocyanine Green-guided Near-infrared Fluorescent Imaging in Video-assisted Thoracoscope Radical Esophagectomy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Indocyanine green (ICG) has been recently introduced in clinical practice as a fuorescent tracer. Lymphadenectomy is particularly challenging in esophageal cancer surgery, owing to the complex anatomical drainage.Therefore, the purpose of this study was to explore whether the NIR-ICG imaging system could accurately assess the lymph node markers during radical resection of esophageal cancer.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophageal Cancer | Malignant Esophageal Neoplasm | CURATED_EXACT | 0.92 |
| Indocyanine Green | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Indocyanine green solution | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- NIR-ICG
- description
- After positioning,Indocyanine green(ICG) dye (Yichuang Pharmaceutical, Liaoning, China) stored at a dose of 25 mg in a small bottle was diluted with 5 ml sterile water. Then, 2 ml of this solution was added to 8 ml sterile water in a dis-posable dressing bowl, resulting in a final concentration of 1.25 mg/ml.
- interventionNames
- Drug: Indocyanine green solution
- type
- NO_INTERVENTION
- label
- Control
- description
- This group of patients received only conventional radical resection of esophageal cancer without Indocyanine green injection.
Primary outcomes (4)
- measure
- Accuracy rate of lymph node dissection
- timeFrame
- 1 week after operation
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age and gender: 18-75 years old, male and female unlimited; 2. Preoperative biopsy was pathologically diagnosed as esophageal squamous cell carcinoma; 3. Preoperative combination with neoadjuvant chemoradiotherapy; 4. Surgical resection of esophageal carcinoma under endoscopic selection and intraoperative anastomosis; 5. Heart, lung, liver and kidney functions can tolerate operation; 6. Patients and their family members can understand and are willing to participate in this clinical study and sign the informed consent. Exclusion Criteria: 1. Allergic to ICG or iodine; 2. Patients with a history of chest surgery or thoracic lymph node dissection; 3. Patients needing emergency surgery; 4. Patients whose tumors involve neighboring organs and need to be removed by combining organs; 5. Patients with tumor recurrence or distant metastasis; 6. Patients who had participated in or were participating in other clinical trials within the previous 4 weeks were included; 7. A history of serious mental illness; 8. Pregnant or lactating women; 9. Patients with other conditions considered by the researcher should not participate in the study.
References
Publications (2)
- DERIVEDDu J, Zeng T, Zhang S, Chen M, Huang G, Xu C, Xu G, Ni C, Hong R, Zheng W, Chen C, Zheng B. Comparison of indocyanine green-near-infrared fluorescence guided and traditional mediastinal lymphadenectomy during radical esophagectomy: A randomized controlled trial. Surgery. 2024 Feb;175(2):347-352. doi: 10.1016/j.surg.2023.10.007. Epub 2023 Nov 26. PMID 38012899
- DERIVEDDu J, Xu G, Yang Z, Zheng B, Chen C. Pericancerous lymph node imaging with indocyanine green-guided near-infrared fluorescence in radical esophagectomy: Protocol for a single-center, prospective, randomized controlled clinical trial. Thorac Cancer. 2022 Aug;13(15):2283-2287. doi: 10.1111/1759-7714.14548. Epub 2022 Jun 29. PMID 35770339