Clinical trial · Interventional
Green Tea Mouthwash on the Oral Health Status in Oral Cancer Patients
Effectiveness of Green Tea Mouthwash on the Oral Health Status in Oral Cancer Patients: A Single-blind Randomized Clinical Trial and a CONSORT-compliant Article
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Objectives: To evaluate the effectiveness of green tea mouthwash on the oral health status (OHS) in oral cancer patients undergoing anticancer treatment. Materials and methods: This was a prospective, single-blind, randomized, controlled trial. Patients were randomly assigned to 2 groups: mouthwash with green tea (intervention) group or tap water (control) group. The intervention group rinsed the mouth with 100 ml green tea solution for 60 seconds at least twice daily, and the control group rinsed the mouth with 100 ml tap water for 60 seconds at least twice daily. The primary outcome was OHS, which was evaluated according to the Oral Assessment Guide and measured at seven time points by the same researcher. Time 0 (T0) corresponded to baseline, and Time 1-6 (T1-T6) corresponded to monthly outpatient follow-ups until six months.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Oral Cancer | Malignant Lip and Oral Cavity Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| mouthwash with green tea | Other | — | UNRESOLVED |
| mouthwash with tap water group | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- mouthwash with green tea group
- description
- The intervention group rinsed the mouth with 100 ml green tea solution for 60 seconds at least twice daily.
- interventionNames
- Other: mouthwash with green tea
- type
- PLACEBO_COMPARATOR
- label
- mouthwash with tap water group
- description
- The control group rinsed the mouth with 100 ml tap water for 60 seconds at least twice daily.
- interventionNames
- Other: mouthwash with tap water group
Primary outcomes (7)
- measure
- oral health status (OHS)
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: * patients who were \> 20 years * newly diagnosed with oral cancer by a physician * just received oral surgery and follow-up with or without chemotherapy or radiation therapy. Exclusion Criteria: * patients with mental illness * an acute and a severe illness status * no teeth in the whole mouth * the ability of mouth opening less than 1 cm.
References
Publications (1)
- DERIVEDLiao YC, Hsu LF, Hsieh LY, Luo YY. Effectiveness of green tea mouthwash for improving oral health status in oral cancer patients: A single-blind randomized controlled trial. Int J Nurs Stud. 2021 Sep;121:103985. doi: 10.1016/j.ijnurstu.2021.103985. Epub 2021 May 25. PMID 34186380