Clinical trial · Observational
A Multi-center, Retrospective Analysis of Clinical Character, Outcome and Prognosis of Lymphoepithelioma-like Carcinoma
NCT04614818CI-TRIAL-00048095unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators retrospective collect the clinical data of patients diagnosed with lymphoepithelioma-like carcinoma, including primary site, gender, age, smoking history, tumor stage, time of initial treatment, EBV-DNA copy number, first-line treatment and survival status.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Lymphoepithelioma-Like Carcinoma | Lymphoepithelial Carcinoma | ALIAS | 0.90 |
| Lymphoepithelioma-Like Carcinoma of Thymus | Thymus Lymphoepithelial Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Non-intervention research | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (9)
- label
- pulmonary lymphoepithelioma-like carcinoma
- description
- The primary site of lymphoepithelioma-like carcinoma locates in the lungs.
- interventionNames
- Other: Non-intervention research
- label
- lymphoepithelioma-like carcinoma of thymus
- description
- The primary site of lymphoepithelioma-like carcinoma locates in the thymus.
- interventionNames
- Other: Non-intervention research
- label
- lymphoepithelioma-like carcinoma of salivary glands
- description
- The primary site of lymphoepithelioma-like carcinoma locates in the parotid gland or submandibular gland.
- interventionNames
- Other: Non-intervention research
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * 1\. Lymphoepithelioma-like carcinoma confirmed by histopathology; * 2\. The primary lesion does not involve the nasopharynx; * 3\. Complete data for patient's character, laboratory and imaging test, treatment and follow-up are available. Exclusion Criteria: * 1\. Concomitant with other tumor components at the time of diagnosis; * 2\. Have a history of any other malignant tumors; * 3\. Lack of complete data
References
Publications (5)
- BACKGROUNDWu Q, Wang W, Zhou P, Fu Y, Zhang Y, Shao YW, Jiang L. Primary pulmonary lymphoepithelioma-like carcinoma is characterized by high PD-L1 expression, but low tumor mutation burden. Pathol Res Pract. 2020 Aug;216(8):153043. doi: 10.1016/j.prp.2020.153043. Epub 2020 Jun 2. PMID 32703503
- BACKGROUNDFang W, Hong S, Chen N, He X, Zhan J, Qin T, Zhou T, Hu Z, Ma Y, Zhao Y, Tian Y, Yang Y, Xue C, Tang Y, Huang Y, Zhao H, Zhang L. PD-L1 is remarkably over-expressed in EBV-associated pulmonary lymphoepithelioma-like carcinoma and related to poor disease-free survival. Oncotarget. 2015 Oct 20;6(32):33019-32. doi: 10.18632/oncotarget.5028. PMID 26361045
- BACKGROUNDHe J, Shen J, Pan H, Huang J, Liang W, He J. Pulmonary lymphoepithelioma-like carcinoma: a Surveillance, Epidemiology, and End Results database analysis. J Thorac Dis. 2015 Dec;7(12):2330-8. doi: 10.3978/j.issn.2072-1439.2015.12.62. PMID 26793355
- BACKGROUNDAbouelfad DM, Yassen NN, Amin HAA, Shabana ME. Lymphoepithelioma-Like Carcinoma of the Breast Mimicking Granulomatous Mastitis- Case Report and Review of the Literature. Asian Pac J Cancer Prev. 2017 Jul 27;18(7):1737-1741. doi: 10.22034/APJCP.2017.18.7.1737. PMID 28749097
- DERIVEDChen M, Chen Y, Fang X, Wang Z, Pu X, Liang C, Guo H, Li Q, Pan F, Hong H, Huang H, Li J, Lin T. Clinical features and treatment outcome of lymphoepithelioma-like carcinoma from multiple primary sites: a population-based, multicentre, real-world study. BMC Pulm Med. 2022 Sep 22;22(1):360. doi: 10.1186/s12890-022-02097-6. PMID 36138362