Clinical trial · Interventional
Utility of Contrast-Enhanced Sonography and Shear Wave Elastography
Utility of Contrast-Enhanced Sonography and Shear Wave Elastography in Conjunction With ACR TI-RADS for the Evaluation of Thyroid Nodules
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): The research team (PI and Sponsor) have agreed that this study would not be feasible to continue.
Summary
Brief summary (as posted)
Our overall hypothesis is that Contrast-enhanced ultrasound (CEUS) and Shear Wave Elastography (SWE) will allow for high diagnostic accuracy of benign and malignant thyroid nodules, which will correlate with and complement the ACR TI-RADS classification system, allowing for more accurate diagnosis of benign and malignant thyroid nodules.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thyroid Nodule | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Contrast-enhanced ultrasound | Other | — | UNRESOLVED |
| Sequoia System | Device | — | UNRESOLVED |
| Shear Wave Elastography | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- CEUS and SWE
- description
- CEUS \& SWE
- interventionNames
- Other: Contrast-enhanced ultrasound
- Other: Shear Wave Elastography
- Device: Sequoia System
Primary outcomes (1)
- measure
- Agreement: 1) between two radiologists for visually assessed CEUS result and 2) between the radiologists reconciled visual assessment result and the gold standard result (biopsy).
- timeFrame
- 8 months
- description
- Kappa analysis will be used to assess the agreement between the two radiologists visual assessment result. The rating result of each radiologist will be compared to the pathological result using Kappa analysis as well.
Secondary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * \- Patients over the age of 18 with one or more thyroid nodules diagnosed on conventional ultrasound within the last 6 months. * Patients referred for standard of care thyroid nodule biopsy, ordered at the discretion of the treating physician and/or radiologists. * Patients must demonstrate ability to understand and express willingness to sign a written informed consent to undergo SWE and CEUS imaging prior to their thyroid nodule biopsy. Exclusion Criteria: * Patients who are pregnant, nursing, or less than 18 years of age * Thyroid nodules ≤1 cm
References
Publications (0)
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