Clinical trial · Observational
Vertebral Fat Quantitative MRI as a Marker of Bone Fragility in Multiple Myeloma (MYELOMEFRAGIQUANTI)
Assessment of Vertebral Fat Quantitative MRI as a Marker of Bone Fragility in Patients With Multiple Myeloma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Multiple myeloma is a disease that causes increased bone fragility which is often revealed or complicated by vertebral fractures. Invasion of bone marrow by tumor plasma cells leads to bone destruction and reduced fat fraction. The main objective is to assess the correlation between vertebral bone marrow fat fraction and bone fragility represented by a severity score of vertebral fractures. The secondary objective is to assess the correlation with clinical and biological prognostic factors and scores..
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Multiple Myeloma | Multiple Myeloma | CURATED_EXACT | 0.92 |
| Vertebral Fracture | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bone marrow fat quantification by MRI | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Multiple myeloma patients with vertebral fractures
- description
- Patients followed for multiple myeloma in the Lariboisière/Saint-Louis/Fernand-Widal hospital group, with vertebral fractures treated by vertebroplasty from January 2017 to December 2021, with recent clinical and biological data available at the time of imaging and fracture events
- interventionNames
- Other: Bone marrow fat quantification by MRI
Primary outcomes (2)
- measure
- Percentage of bone marrow fat in vertebral bone marrow
- timeFrame
- At the moment of the diagnosis of the vertebral fracture before treatment by vertebroplasty
- description
- Measured from Dixon sequences on MRI exams performed in routine care, for the assessment of the relationship between bone marrow vertebral fat content and the severity of the vertebral fractures
- measure
- Vertebral fracture severity score
- timeFrame
- At the moment of the diagnosis of the vertebral fracture before treatment by vertebroplasty
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients followed for multiple myelomas in the Lariboisière/Saint-Louis/Fernand-Widal hospital group * vertebral fractures treated by vertebroplasty from January 2017 to December 2021 * recent clinical and biological data available at the time of imaging and fracture events Exclusion Criteria: * Factors modifying the bone marrow fat fraction (extensive radiotherapy) * Lack of recent clinical or biological data compared to imaging examinations
References
Publications (0)
Data not yet available