Clinical trial · Interventional
Dexmedetomidine Infusion Effect on Hemodynamic Variables During Craniotomy
Efficacy of Dexmedetomidine Infusion Without Loading Dose on Hemodynamic Variables and Recovery Time During Craniotomy: A Randomized Double Blinded Controlled Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
There is no clear consensus among neuroanesthesiologists regarding which anesthetic regimen is optimal for craniotomy. Propofol and short-acting opioids (such as remifentanil, fentanyl, or sufentanil) are commonly used. However, use of opioids is associated with increased risk of respiratory depression and postoperative nausea and vomiting. Dexmedetomidine is a highly selective α2-adrenoreceptor agonist that has been considered as a useful and safe adjunct to anesthesia for various surgical procedures
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hemodynamic Instability | — | UNRESOLVED | — |
| Supratentorial Neoplasms | Supratentorial Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dexmedetomidine | Drug | — | UNRESOLVED |
| normal saline | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Group D
- description
- Group D: Patients received 0.5 µg/kg/h of Dexmedetomidine. Dexmedetomidine dosage was diluted in 50 ml syringe of normal saline
- interventionNames
- Drug: Dexmedetomidine
- type
- PLACEBO_COMPARATOR
- label
- Group C
- description
- Patients received equal volume and rate of normal saline as Group D.
- interventionNames
- Drug: normal saline
Primary outcomes (3)
- measure
- Mean areterial blood pressure
- timeFrame
- 4 to 8 hours
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * American society of anesthesiologists- Physical status (ASA-PS) I and II patients, * aged 18 to 65 years * 70-80 kg * both sexes * undergoing elective supratentorial craniotomy for tumor resection Exclusion Criteria: * Patients under 18 years of age * pregnancy, * emergency surgery * patients with a Glasgow Coma Score (GCS) less than 15. * Those who had respiratory or cardiac dysfunction, renal insufficiency, liver impairment, or bleeding disorders
References
Publications (0)
Data not yet available