Clinical trial · Interventional
A Distress Reduction Intervention for Patients With BCR-ABL-Negative MPNs or CML on Tyrosine Kinase Inhibitors
Being Present-MPN: A Distress Reduction Intervention for Patients With BCR-ABL-Negative MPNs and CML on Tyrosine Kinase Inhibitors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This trial looks at how well a distress reduction intervention, called "Being Present", works to improve the quality of life of patients with BCR-ABL-negative myeloproliferative neoplasms (MPNs) or chronic phase chronic myeloid leukemia (CP-CML) who are taking tyrosine kinase inhibitors (TKIs) and their caregivers. Mindfulness meditation is the practice of repeatedly bringing attention back to the immediate experience and may help people cope with various types of illness, stress, and worry. This may help patients and caregivers to gradually learn to disconnect from reacting to and dwelling on the past and future and instead fully experiencing the present moment.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chronic Myeloid Leukemia | Chronic Myeloid Leukemia, BCR-ABL1 Positive | ALIAS | 0.90 |
| Chronic Phase Chronic Myelogenous Leukemia | Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive | ALIAS | 0.90 |
| Myeloproliferative Neoplasm | Myeloproliferative Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Internet-Based Webinars | Other | — | UNRESOLVED |
| Online Mindfulness Meditation | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Being Present (Supportive Care)
- description
- Patients and caregivers receive Being Present intervention consisting of online audio-based mindfulness meditation exercise over 15 minutes at least 5 times per week, daily meditation reminders, and online webinars over 30-60 minutes every week.
- interventionNames
- Behavioral: Online Mindfulness Meditation
- Other: Internet-Based Webinars
Primary outcomes (14)
- measure
- Frequency of Primary Symptoms
- timeFrame
- Up to 90 days
- description
- The frequency of primary symptoms will be categorized and assessed by semi-structured qualitative interviews.
- measure
- Frequency of Participants' Understanding of Hematologic Malignancies
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * PATIENT: Carry a diagnosis of BCR-ABL-negative MPN or CML * PATIENT: Have an estimated life expectancy of at least 6 months, assessed by principal investigator or treating investigator * PATIENT: Be able to speak and read English * PATIENT: Be able to navigate websites, fill out forms on the web, communicate by email, and have regular access to the internet (assessed by participant self-report) * PATIENT: Have daily access to a mobile phone capable of receiving text messages, as determined by a study investigator * PATIENT: Be able to provide informed consent * CAREGIVER: Be a spouse/partner, other family member, or a close friend of a BCR-ABL-negative patient who consented to participate in the Being Present-MPN study * CAREGIVER: Be able to speak and read English * CAREGIVER: Be able to navigate websites, fill out forms on the web, communicate by email, and have regular access to the internet (assessed by participant self-report) * CAREGIVER: Have access to a mobile phone capable of receiving text messages, as determined by a study investigator * CAREGIVER: Be able to provide informed consent Exclusion Criteria: * PATIENT: Have had their BCR-ABL-negative MPN transform into acute leukemia * PATIENT: Have had their CP-CML transform into blast phase * PATIENT: Be post-allogeneic stem cell transplantation * PATIENT AND CAREGIVER: Have extensive hearing loss such that ability to participate in the study would be impaired
References
Publications (0)
Data not yet available