Clinical trial · Observational
Molecular and Epidemiological Risk Factors in the Development of Gastric Cancer
Identification of Molecular and Epidemiological Risk Factors in the Development of Gastric Cancer in High-risk Predominantly Hispanic Population
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): PI leaving institution
Summary
Brief summary (as posted)
This protocol is a single-institution feasibility study to identify the molecular and epidemiological risk factors in the development of gastric cancer in high-risk predominantly Hispanic South Texas population. The study is broken down into two main parts: 1) To identify molecular differences in gastric adenocarcinoma (GAC) between Non-Hispanics and Hispanics, stratified by age, and in benign, pre-malignant, and malignant gastric lesions; and 2) To identify environmental and clinicopathological factors in Hispanics associated with specific molecular changes linked to the development of GAC.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Germline Testing | Other | — | UNRESOLVED |
| Molecular testing for all participants. | Other | — | UNRESOLVED |
| Survey | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- Retrospective Non-Hispanics
- description
- Molecular testing will be done on formalin fixed paraffin-embeded (FFPE) tissue collected at the time of gastroadenocarcinoma diagnosis and subsequent biopsies. Participants who are alive will be asked to complete a survey and consent to germline testing.
- interventionNames
- Other: Molecular testing for all participants.
- Other: Germline Testing
- Other: Survey
- label
- Retrospective Hispanic
- description
- Molecular testing will be done on formalin fixed paraffin-embeded (FFPE) tissue collected at the time of gastroadenocarcinoma diagnosis and subsequent biopsies. Participants who are alive will be asked to complete a survey and consent to germline testing.
- interventionNames
- Other: Molecular testing for all participants.
- Other: Germline Testing
- Other: Survey
- label
- Prospective Non-Hispanic
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Aged 18 years or older * Patient with histologically confirmed diagnosis of gastric adenocarcinoma * Able to understand English or Spanish (only for the prospective cohort) * GEJ adenocarcinoma Type II (within 1 cm above and 2 cm below the GEJ) and Type III (2-5 cm below the GEJ) * Hyperplastic polyps Exclusion Criteria: * Clinically AND genetically confirmed diagnosis of well-established hereditary cancer syndrome * Gastroesophageal junction (GEJ) adenocarcinoma Type I (1-5 cm above the GEJ) as they are treated as esophageal cancer * Other benign or malignant histology types (i.e. leiomyoma, gastrointestinal stroma tumors, fundic gland polyps, etc.)
References
Publications (0)
Data not yet available