Clinical trial · Interventional
Effect of Tramadol Versus Morphine on PD1 and PD1-ligand in Patients With Chronic Cancer Pain
Comparison Between the Effect of Tramadol Versus Morphine on PD1 and PD1-ligand in Patients With Chronic Cancer Pain
NCT04589494CI-TRIAL-00049420unknownPhase 2 / Phase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
this work is looking for comparison between the effect of tramadol versus morphine on PD1 and PD1-ligand in patients with chronic cancer pain
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chronic Pain | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Tramadol Hydrochloride | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- tramadol group
- description
- tramadol hydrochloride 100 mg three times daily
- interventionNames
- Drug: Tramadol Hydrochloride
- type
- ACTIVE_COMPARATOR
- label
- morphine group
- description
- morphine 30 mg twise times daily
- interventionNames
- Drug: Tramadol Hydrochloride
Primary outcomes (1)
- measure
- changes in PD1 and PD1ligand
- timeFrame
- baseline(0), day15 , day 30
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * patients with cancer pain of varying etiology, * documented metastatic cancer, currently on step I WHO ladder and whose pain necessitates a shift to step II, * those who have never received radiotherapy, chemotherapy, or immunosuppressive drugs, -- and in good general and nutritional condition and without infectious diseases at the time of investigation. Exclusion Criteria: * abnormal hepatic, renal, and pulmonary function, gastrointestinal pathology, and * those with cerebral metastases and/or psychological disorders, * patients with contraindication to morphine or tramadol according to their respective data sheets, and * patients who could not complete the diary information correctly.
References
Publications (0)
Data not yet available
No reference posted for this study.